World Journal of Current Medical and Pharmaceutical Research

A study of cardiovascular risk in dyslipidemia patients and role of statins in lowering the lipid levels.

Fri, 28 Feb 2025 00:00:00 +0530

This study aimed to predict CVD risk in dyslipidemia patients based on factors like HTN, DM, hypothyroidism, alcohol, smoking, and obesity. We recruited 75 dyslipidemia patients (July–December 2023) and analyzed their CVD risk via 2D-ECHO & ECG. Statin combination therapy (Ecosprin, Ecosprin + Rosuvastatin) was prescribed for CVD-confirmed patients, while statin monotherapy (Atorvastatin) was given to those without CVD risk, aligning with Kirsten Bibbins-Domingo et al.'s study. Participants were categorized by age: 18–30 (11), 31–43 (17), 44–56 (22), and >56 (25). Gender-wise, females (40) outnumbered males (35), similar to Seyed Mahmoud Latifi et al.'s study. Based on residence, 47.67% were urban and 57.53% rural, with rural participants being higher. HTN was found in 52 patients, with 34 at CVD risk. DM was present in 34, with 24 at risk, aligning with Razieh Anari et al.'s findings. Hypothyroidism affected 22 patients, with 11 at risk, similar to Fatima Tarboush et al.'s study. Obesity was noted in 24 patients, with 17 at risk. Alcohol consumption was reported in 36 patients, with 28 at risk, while 31 were smokers, with 23 at risk. These findings highlight significant CVD risk factors in dyslipidemia patients.

a review on breast cancer in a young women and oppurnities in treatment

Tue, 11 Feb 2025 00:00:00 +0530

Breast cancer is the most commonly diagnosed cancer and the leading cause of death among female patients, which seriously threatens the health of women in the whole world. The treatments of breast cancer require the cooperation of a multidisciplinary setting and taking tumour load and molecular makers into account. The incidence of breast cancer is constantly increasing in all regions of the world. For this reason, despite the progress in its detection and treatment, which translates into improved mortality rates, it seems necessary to look for new therapeutic methods, and predictive and prognostic factors. Triple negative breast cancer is responsible for more than 15–20% of all breast cancers. Future therapeutic concepts for breast cancer aim to individualize therapy and de-escalate and escalate treatment based on cancer biology and early response to therapy. The article presents a review of the literature on breast carcinoma—a disease affecting women in the world.

Ḥammāmtherapy: Integrating Tradition and Evidence in Therapeutic Practices

Ahmed Wani Irshad, Husain Bushra, Ahmad Mir Rayees, Nayab Mohd, Begum Mehmooda — Thu, 13 Feb 2025 00:00:00 +0530

Ḥammām therapy, a traditional bathing practice with historical roots in Roman and Islamic cultures, is designed to provide both physical and therapeutic benefits through a sequence of hot, warm, and cool rooms. Fundamental to the Unani medical system, it uses a series of hot, warm, and cool exposures to enhance circulation, aid in detoxification, and treat skin and musculoskeletal disorders. The therapeutic mechanism of the Ḥammāmis based on principles of balancing bodily humors and restoring health through Tarteeb (regulating moisture) and Taskhīn (heat therapy). Although the practice offers numerous health benefits, its use requires careful consideration of individual temperaments and medical conditions. This review examines the historical evolution, architectural structure, procedural aspects, and types of Ḥammāmbaths, including their specific health benefits & modern clinical studies validating its efficacy in conditions like metabolic syndrome, cardiovascular disorders, and post-stroke rehabilitation, emphasizing its relevance in contemporary integrative medicine.

Diabetic ketoacidosis in pregnancy with respiratory and latent syphilis infection: a case report

Made Priska Arya Agustini, Dewi Catur Wulandari — Fri, 14 Feb 2025 00:00:00 +0530

Introduction: DKA in pregnancy is a rare and life-threatening condition. In general, this case occurs more often in patients with a history of Type I Diabetes Mellitus (DM) compared to Type II DM or gestational DM.

Case: A 33-year-old pregnant woman (G2P1A0) 20 weeks and 6 days of gestation complaints of shortness of breath accompanied by fever, dry cough, and nausea and vomiting. She had not felt fetal movements since one day before admission. The patient had a history of type II DM. From examination, a respiratory rate of 28 breaths per minute with Kussmaul breathing, a heart rate of 92 beats per minute, body temperature of 37.7°C, and tenderness in the epigastrium. Complete blood count showed WBC 20.21 x 10³/µL with blood gas analysis was acidosis metabolic, urinalysis showed ketones +4, Glucose +4, Protein +1, and TPHA reactive. Chest X-ray examination found bronchitis and abdominal USG showed no fetal heartbeat and fetal movement. The patient showed significant improvement after administration of therapy.

Discussion: Physiologically, pregnancy carries a risk for DKA due to increased insulin resistance and ketogenesis. This risk will increase with the presence of precipitating factors such as infection. The infection will trigger the release of pro-inflammatory cytokines and counter-regulatory hormones such as cortisol or adrenaline which trigger ketoacidosis.

Conclusion: A multidisciplinary approach to managing DKA is crucial to minimizing maternal and infant mortality. Pre-pregnancy education and counseling should be provided to all women planning to become pregnant, whether with or without a history of diabetes.