World Journal of Current Medical and Pharmaceutical Research

Analysis of Heavy metal, Aflatoxin, Pesticide Residue and Microbial Contamination of Siddha Herbal Formulation Muppirandai Chooranam

Shanthini R, Anbu N — Wed, 13 Sep 2023 00:00:00 +0530

Aim: The aim of the study was to evaluate the presence of Heavy metal, Aflatoxin, Pesiticide residue and Microbial contamination of Siddha herbal formulation Muppirandai Chooranam (MRC).

Place of study: Heavy metal analysis, Aflatoxin assay, Pesiticide residue, Microbial contamination analysis were conducted at Noble Research Solutions, Kolathur, Chennai -99.

Methodology: The Siddha formulation Muppirandai Chooranam was prepared as per Good Manufacturing Practices(GMP) guidelines and the Heavy metal analysis, Aflatoxin assay, Pesiticide residue, Microbial contamination analysis were conducted at Noble Research Solutions, Kolathur, Chennai -99.

Results: The results of Heavy metal analysis of Muppirandai Chooranam (MRC) shown the presence of Lead at 3.54 PPM and Arsenic, Cadmium, Mercury at Below Detection Limit (BDL). Aflatoxin assay of MRC shown the absence of Aflatoxin B1, Aflatoxin B2, Aflatoxin G1, Aflatoxin G2. Pesticide residue analysis showed that there were no traces of Pesticide residues such as Organo chlorine, Organo phosphorus, Organo carbamates and Pyrethroids. In Microbial contamination analysis, Test for Specific Pathogen shown the absence of Organisms E-coli, Salmonella, Staphylococcus Aureus, Pseudomonas Aeruginosa and No Bacterial and fungal growth or colonies were observed in the Sterility test of MRC as per the methods of AYUSH specifications.

Conclusion: From the results, it is concluded that the study medicine MRC has Heavy metal content below the permissible limit as per PLIM guidelines of AYUSH, and the sample were free from Aflatoxins, Pesiticides, Microbes, and Specific Pathogens which ensures that the study medicine Muppirandai Chooranam was safe therapeutically.

Evaluation Cholesterol and Triglycerides Levels for Type One Diabetes Patients

Mohsin Aziza Mohammed , Safaa Hussein Ali, Aamir M. Abed Al-ghareebawi — Tue, 19 Sep 2023 00:00:00 +0530

This study is designed to highlight the association between high level of blood glucose and cholesterol and triglycerides. Thirty persons divided into six groups according to age. Groups A, B, C, D, E are patients groups that compared with the control group N. Three blood biomedical parameters were assessed in the current study that including random blood sugar (RBS), cholesterol and triglycerides levels. Statistical analysis showed significant differences between control group and patients' groups. Also, analysis confirmed a strong relation between glucose levels and cholesterol and triglycerides levels respectively. These results confirm the scientific recommendations about the life style, diabetes management and eating habits

A Review on Siddha Polyherbal Formulation - Gowthamar Chooranam for the Treatment of Swasakasam (Bronchial Asthma)

Anitha Kalaivani — Sun, 17 Sep 2023 15:01:44 +0530

Background: In Siddha system of medicine Swasakasam is correlated with bronchial asthma. Bronchial asthma is a common respiratory disorder. It is a chronic inflammatory disease of the airways associated with airway hyper- responsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness and coughing, particularly at night and in the early morning which may subside spontaneously or with treatment. This review shows the potential role of Gowthamar chooranam a siddha polyherbal formulation from the siddha literature the pharmacopoeia of siddha research medicine for the treatment of Swasakasam (Bronchial asthma).

Aim and Objective: This review provides an information on uses, chemical components, and pharmacological properties of the medicinal herbs. It also identifies research gaps and opens up new possibilities for future study of these polyherbal formulation for treatment of Swasakasam (Bronchial asthma).

Materials and Methods: The review conducted from the primary sources called ancient siddha literature and also the search from electronic sources called databases like Google scholar, Pubmed, Science direct with key words anti-asthmatic herbs, , pharmacological actions. The information was collected and reviewed.

Result: Most of the herbs included in the siddha formulation was found to be anti-asthmatic activity

Conclusion: All the ingredients present in siddha polyherbal formulation gowthamar chooranam is simple, easily available, inexpensive, easy to prepare. The pharmacological properties of ingredients have pungent taste, hot poteny and are mostly found as anti-inflammatory, immunomodulatory, anti-allergic, anti-asthmatic. Hence it evident that the formulation was very effective in the treatment of Swasakasam (Bronchial asthma). Further preclinical, clinical studies and statistical data analysis helps in exploring this polyherbal siddha formulation.

General overview of the Risk factors, Pathogenesis, and Combined treatments for Hashimoto's Thyroiditis (HT)

Yash Srivastav, Akhandnath Prajapati, Kumari Meera, Kumar Madhaw — Mon, 18 Sep 2023 00:00:00 +0530

In regions of the world where iodine is abundant, Hashimoto's thyroiditis, also known as Hashimoto's disease or autoimmune thyroiditis, is the most prevalent cause of hypothyroidism. It is a chronic inflammation of the thyroid gland. It is characterized by autoimmune-mediated thyroid gland destruction, which results in progressive thyroid failure, either with or without goiter formation. In young to middle-aged women, Hashimoto's thyroiditis typically starts as a painless, diffuse, firm thyroid gland enlargement that progresses to hypothyroidism. Many people don't initially exhibit hypothyroidism, and some don't even have a goiter or may have an atrophic thyroid gland. Hashimoto's thyroiditis (HT), also known as chronic autoimmune thyroiditis, is an inflammatory condition that is characterized by parenchymal atrophy, fibrosis, and diffuse lymphocytic infiltration. being the main source of primary hypothyroidism in regions with adequate iodine. With the help of various criteria, such as physical examination, blood tests for thyroid hormone levels (TSH is low, T3 and T4 are tall, for example), serum cholesterol and triglycerides, blood glucose, and radioactive iodine uptake, it is possible to distinguish between infections and clutter. According to estimates from several thyroid disease studies, 42 million persons in India are estimated to have the ailment. The pathogenesis causes, risk factors and combination therapy linked to Hashimoto's thyroiditis are discussed in this review study.