World Journal of Current Medical and Pharmaceutical Research https://wjcmpr.com/index.php/journal <p align="justify">World Journal of Current Medical and Pharmaceutical Research (WJCMPR)<span data-preserver-spaces="true">&nbsp;is a&nbsp;</span>double-blind Referred peer-reviewed tri-annual (from 2024 onwards), open-access international journal<span data-preserver-spaces="true">&nbsp;dedicated to the promotion of research in Medical and Pharmaceutical Sciences. WJCMPR publishes Research articles, Review articles, Case studies, and Short communication from broad areas like Medical Sciences and Pharmaceutical Sciences.</span></p> en-US <h2><span style="font-size: 14px;">Copyright © Author(s) retain the copyright of this article.</span></h2> editor@wjcmpr.com (WJCMPR) wjcmpr@gmail.com (Support Manager) Tue, 14 May 2024 10:25:07 +0530 OJS 3.1.2.4 http://blogs.law.harvard.edu/tech/rss 60 A Prospective Observational Study to Evaluate Safety and Efficacy of Intraarticular Administration of Triamcinolone Acetonidein Knee Osteoarthritis in A Tertiary Care Hospital https://wjcmpr.com/index.php/journal/article/view/324 <p>Objective: Osteoarthritis is a chronic disease marked by cartilage deterioration, affecting millions globally.&nbsp; Although incurable, it can be managed with adjuvant therapy. This study aims to assess the safety and efficacy of intra-articular Triamcinolone acetonide in knee OA, a corticosteroid used for OA, Rheumatoid arthritis, gouty arthritis, and skin disorders.</p> <p>Methods: In a prospective observational study with 120 participants, pain severity was evaluated using numerical pain rating and KL-grade scales, while joint space narrowing was assessed via X-ray reports. Subjects were categorized by severity and prescribed intra-articular Triamcinolone acetonide, analgesics, NSAIDs, PPIs, and supplements. They were monitored for pain reduction.</p> <p>Results: Pain scores were evaluated using NPRS and KL-grade scale: initially, severe pain affected 4.1% (n=5), moderate 86.6% (n=104), mild 9.1% (n=11). After three follow-ups over 6 months, severe pain decreased to 1.6% (n=2), moderate to 84.1% (n=101), and mild increased to 14.1% (n=17).</p> <p>Conclusion: Our study concludes that intra-articular triamcinolone acetonide, combined with oral and topical analgesics, PPIs, nutritional, and vitamin supplements, is safer and more effective for knee OA, improving patient quality of life, reducing disease severity, prescription charges, and adverse drug reactions.</p> Lazaru P, N. Suresh Kumar J, Chenna Reddy D, Aliveli Bai B, Naga Nandini Ch, K.S Prathyusha G, Jyothirmai V P, Sowmya S Copyright (c) 2024 https://creativecommons.org/licenses/by-nc/4.0 https://wjcmpr.com/index.php/journal/article/view/324 Mon, 13 May 2024 00:00:00 +0530 Teamwork significantly improves pathology slide diagnosis: students’ perspective https://wjcmpr.com/index.php/journal/article/view/327 <p><strong>Background &amp; objectives: </strong>Team-based learning is a pedagogical strategy that enhances student knowledge through individual testing and group collaboration. The objective of this preliminary study was to examine if students’ collaborative annotation improved understanding of microscopic morphology and diagnosis of pathological slides.</p> <p><strong>Methods: </strong>Mean individual and then group scores of pathology slides analysis by Path2 students were compared by the Wilcoxon signed rank test and group differences by ANOVA. Students' attitudes toward TBL were examined using a short 8-item questionnaire which graded responses on a 5-point Likert scale. Analyses were performed in the SPSS version 20.Probability level of p&lt;0.05 was statistically significant.</p> <p><strong>Results: </strong>The average individual scores ranged from 44.0 to 50.0 out of 100. The differences between the groups were not observed. The average group scores ranged from 75.0 to 82.0percentage. Compared with the average individual score, all group scores were statistically<br>significantly higher (p&lt;0.001). Group scores among students who had low performance were statistically significantly higher compared to their individual scores. This was also observed among high performance students (p&lt;0.003). In terms of TBL attitudes, all average attitude scores were positive (the highest were reported for active learning). Attitudes score did not<br>correlate with the Path1 grade. No difference in attitudes was found between high and low performing students.</p> <p><strong>Conclusion: </strong>Group analysis of pathology slides significantly improves the success in making a pathological diagnosis, both for low performance and for high performance students. The strongest positive attitude was observed for “Promotes opportunity for active learning”, “Group dynamics potentiate learning outcome” and “Encourage discussion for differential diagnosis”. We progressively incorporated these collaborative approaches into virtual environment in pathology courses at our medical faculty that have been shown to further improve students’ engagement and learning outcomes, promotes opportunities for active engagement and interaction.</p> Dragan Jovanovic, Tatjana Gazibara, Adlekha Shashikanth, Olubukola Yeku, Andrew Wolfram, Christina Krupinsky, Teya Van Biljouw Bath Copyright (c) 2024 https://creativecommons.org/licenses/by-nc/4.0 https://wjcmpr.com/index.php/journal/article/view/327 Tue, 21 May 2024 00:00:00 +0530 The versatility of klotho protein: insights into its multifaceted functions in health and disease https://wjcmpr.com/index.php/journal/article/view/328 <p>The Klotho protein, initially discovered for its role in aging and calcium metabolism, has emerged as a multifunctional regulator with diverse impacts on health and disease. Beyond its functions in maintaining phosphate homeostasis and suppressing aging pathways, Klotho exhibits pleiotropic effects in various physiological processes, including cognition, cardiovascular health, and cancer suppression. This review elucidates themechanisms underlying Klotho's versatile functions, shedding light on its involvement in modulating signaling pathways such as insulin/IGF-1, Wnt, and fibroblast growth factor (FGF) pathways. Furthermore, we explore the therapeutic potential of Klotho modulation in combating age-related diseases, neurodegeneration, and metabolic disorders. Understanding the complexities of Klotho biology unveils novel strategies for therapeutic interventions and highlights its significance in promoting healthy aging and disease prevention.</p> Sonali Raj, Mehak Ahuja Copyright (c) 2024 https://creativecommons.org/licenses/by-nc/4.0 https://wjcmpr.com/index.php/journal/article/view/328 Wed, 05 Jun 2024 00:00:00 +0530 Utilization of unani regimenal therapy for the management of insomnia: a rapid scoping review https://wjcmpr.com/index.php/journal/article/view/325 <p><strong>Objective:</strong> To review existing clinical trials in humans having <em>Unani Regimenal Therapy</em> for the management of insomnia.</p> <p><strong>Data sources: </strong>A systematic review was conducted using PubMed, Google Scholar, and Google from January 2010 to March 2024.</p> <p><strong>Study selection:</strong> Keywords like “Insomnia, <em>Sehar</em>, <em>Sahar</em>, <em>Bekhawbi</em>” and “<em>Ilaj bil Tadbeer</em>, Unani Medicine, Greco-Arab Medicine” were used in the search strategy. Only studies in English were selected. Two reviewers independently screened the studies, and conflicts were resolved by consensus. Studies that do not list the <em>Unani Regimenal Therapy</em> were excluded.</p> <p><strong>Data extraction:</strong> A total of 22 articles were identified, and 7 were included in the final analysis. The following data were extracted: author, year of publication, intervention, outcome measures, and result.</p> <p><strong>Data synthesis:</strong> The results of the present review indicate that the implication of <em>Unani Regimenal Therapy</em> positively is beneficial in the management of insomnia.</p> <p><strong>Conclusion</strong>: Insomnia, resembling <em>Sahar</em> in Unani medicine, is typically treated with drugs in conventional medicine, often with adverse effects. However, the reviewed studies reveal the efficacy and safety of <em>Unani Regimenal Therapy</em> in alleviating insomnia symptoms without adverse effects. Early intervention with this therapy yields better outcomes, but more clinical trials are needed due to limited research. While some <em>Regimenal Therapy</em> modalities like <em>Naṭūl</em> (Irrigation Therapy), <em>Tadhīn</em> (Oiling), and <em>Dalk</em> (Therapeutic Massage) are explored, others remain unexplored. Overall, combining medicine with <em>Unani Regimenal Therapy</em> offers a promising approach to managing insomnia.</p> Meraj Meraj, Abdul Rehman M.I, Naseem Ahmad Khan, Sadique Husain, Noushiba Khan Copyright (c) 2024 Meraj Meraj, Abdul Rehman M.I, Naseem Ahmad Khan, Sadique Husain, Noushiba Khan https://creativecommons.org/licenses/by-nc/4.0 https://wjcmpr.com/index.php/journal/article/view/325 Sat, 08 Jun 2024 00:00:00 +0530 Ayurvedic paradigm of arsha: an analytical review of etiology, diagnosis, and treatment https://wjcmpr.com/index.php/journal/article/view/329 <p>Haemorrhoids, known as Arsha in Ayurveda, are a prevalent condition with multifactorial aetiology and diverse clinical manifestations. This literature review aims to provide a comprehensive analysis of the Ayurvedic paradigm of Arsha, focusing on its aetiology, diagnosis, and treatment modalities. Drawing from classical Ayurvedic texts and contemporary research, this review synthesizes existing knowledge to elucidate the pathogenesis of Arsha and its impact on patient health. Through a systematic examination of historical and contemporary sources, key findings emerge regarding the dietary, lifestyle, and Dosha factors contributing to Arsha. Diagnostic methods in Ayurveda, such as Sadhvidha Pariksha, are explored in conjunction with modern medical approaches, highlighting the importance of comprehensive clinical assessment for accurate diagnosis. Treatment options, including preventive measures and therapeutic interventions, are discussed in detail, emphasizing the holistic nature of Ayurvedic management. Implications for clinical practice and areas for future research are outlined, underscoring the need for further exploration into the efficacy of Ayurvedic interventions and their integration into modern healthcare systems. This review provides valuable insights for healthcare practitioners and researchers seeking to enhance the management of haemorrhoids through an integrative approach.</p> Manmahendra Singh, Hemantha Kumar P, Ashok Kumar, Narinder Singh Copyright (c) 2024 https://creativecommons.org/licenses/by-nc/4.0 https://wjcmpr.com/index.php/journal/article/view/329 Tue, 25 Jun 2024 00:00:00 +0530 A critical review on garbhopghatkarabhava related to dietetics https://wjcmpr.com/index.php/journal/article/view/332 <p><em>Garbhopaghatakara Bhavas</em> deals with concerns that may cause <em>Upaghata</em> (damage) to the growing fetus (<em>Garbha)</em>. It includes<em>Ahara, viharaj and mansik</em>factors that are dangerous during pregnancy. Maternal <em>Ahara</em> has a crucial role in regulating maternal health and fetal growth. The word "<em>Ambu</em>" in <em>Garbhasambhavasamagri</em> refers to a nutrient-dense portion for good conceptus growth. Any defect in "<em>Ambubhava</em>" has a negative impact on pregnancy by preventing the growing fetus from receiving adequate nutrients. This paper discuss the <em>Garbhopghatakarabhava</em> related to <em>Ahara</em>with rationality. Scientific knowledge of these factors can improve birth outcomes by removing hazardous variables.</p> Dixit Neha, Poonam Choudhary Copyright (c) 2024 https://creativecommons.org/licenses/by-nc/4.0 https://wjcmpr.com/index.php/journal/article/view/332 Thu, 11 Jul 2024 00:00:00 +0530