World Journal of Current Medical and Pharmaceutical Research <p align="justify">World Journal of Current Medical and Pharmaceutical Research (WJCMPR)<span data-preserver-spaces="true">&nbsp;is a&nbsp;</span>double-blind Referred peer-reviewed tri-annual (from 2024 onwards), open-access international journal<span data-preserver-spaces="true">&nbsp;dedicated to the promotion of research in Medical and Pharmaceutical Sciences. WJCMPR publishes Research articles, Review articles, Case studies, and Short communication from broad areas like Medical Sciences and Pharmaceutical Sciences.</span></p> World Journal of Current Medical and Pharmaceutical Research en-US World Journal of Current Medical and Pharmaceutical Research 2582-0222 <h2><span style="font-size: 14px;">Copyright © Author(s) retain the copyright of this article.</span></h2> Health pulse initiative: tracking blood pressure in akshaya group's teaching and non-teaching staff <p>Hypertension refers to a condition where the systemic artery blood pressure exceeds normal levels, necessitating increased cardiac effort to counteract the elevated pressure and ensure adequate blood flow to tissues. The heightened systemic arterial pressure places stress on the heart and other arteries, contributing to the development of hypertension. In our cross-sectional observational study, we employed questionnaires to gather data from volunteers over a three-month period. The inclusion and exclusion criteria were carefully applied to ensure the relevance of the collected data. Our study included 120 individuals from the selected region, aiming to assess blood pressure monitoring. The study revealed a dominance of males, constituting 51.67% of the total participants, while women accounted for 48.33%. The age distribution showed that 46.67% of the volunteers fell within the 31 to 40 age group. Our findings indicated that age, gender, and occupation significantly influenced blood pressure monitoring. Upon analysis, we observed a statistically significant improvement in volunteers' knowledge, attitudes, and practices regarding hypertension following counseling. This suggests the potential efficacy of intervention strategies in enhancing awareness and management of hypertension among the studied population.</p> Thakur Tark Aseem Jangid Vimla Prithvidas Saurabh Tiwari Ritesh Singh Harendra Yadav Pradeep Lalbahadur Renukaradhya Chitti Prakash Tigari Megha shri Copyright (c) 2024 2024-02-12 2024-02-12 1 8 10.37022/wjcmpr.v6i1.312 Study of the relationship between ghrel in hormone and nitric oxide in patients with chronic kidney disease in thi-qar governorate – IRAQ <p>Objective: When abnormalities in kidney structure or function are evident for more than three months, it is referred to as chronic kidney disease (CKD), a complicated and progressive chronic disorder that can have devastating health effects. Either reduced glomerular filtration rate or indicators of renal injury could be evident. End-stage renal disease (ESRD) patients are increasingly choosing PD, HD, and kidney transplantation as treatments to extend their lives because of the development of renal replacement therapies, such as kidney transplantation, hemodialysis (HD), peritoneal dialysis (PD), and continuous renal replacement therapy (which is frequently used for acute renal failure). Loss of muscle mass may result from dialysis treatments that increase protein breakdown and decrease protein synthesis. These reactions continue after dialysis. The purpose of this research is to look into the connection between the ghrelin. Materials and Method: In order to determine the blood lipid profile and Ghrelin hormone levels, 90 individuals with Chronic Kidney Disease (CKD) on dialysis were divided into 45 males, 45 females, and 90 healthy subjects. The Ghrelin hormone concentration was compared with the other biochemical parameters, and the relationship between the hormones Ghrelin and Nitric Oxide was also found. Results: Ninety healthy subjects and ninety chronic kidney disease (CKD) patients with dialysis had their blood lipid profiles and Ghrelin hormone and nitric oxide levels measured. The results included a comparison of the hormone's concentration with other biochemical parameters and the identification of the hormone's relationship with nitric oxide. Results:&nbsp; When compared to the control group, dialysis patients' nitric oxide levels significantly decreased (p≤0.05). There were no discernible variations in the levels of serum nitric oxide between the sexes. (p &lt; 0.05).Ghrelin levels in the blood serum of dialysis patients were significantly lower than those in the control group (p≤0.05). Additionally, it was demonstrated that the level of the hormone Ghrelin was significantly lower in females than in males (p≤0.05). Conclusion: When comparing dialysis patients to the control group, we detect a significant drop in the levels of Ghrelin Hormone and Nitric Oxide in patients with chronic kidney disease.It follows that low nitric oxide and ghrelin levels in chronic renal disease patients can cause kidney failure to progress to an advanced degree and eventually require dialysis.</p> Ali Manhal Ibrhim Mohammed AAouda Kadhim Mohan Manhil Copyright (c) 2024 2024-03-05 2024-03-05 13 17 10.37022/wjcmpr.v6i1.313 Detection of Hbv Dna By Direct Pcr Protocol And Nested Pcr Protocol And Comparing Them. In Chronic Patients and Healthy Carriers of Hepatitis B Virus. <p>Hepatitis B virus is a major public health problem, and the outcome of infection depends on the effectiveness of the virus's interaction with the host, and in particular on the strength of the natural and conditioned response of humoral and cellular immunity. This study was conducted to assess the clinical status, genetic immunity and viral (viral) traits of Iraqi patients with chronic hepatitis B virus and healthy carriers of hepatitis B surface antigen, as well as to show the relationship between the immune status and the chronic condition of the disease. The study included (60) patients with chronic hepatitis B virus type (B) and (60) healthy hepatitis B surface antigen carriers who attended the Teaching Hospital for Gastrointestinal and Liver Diseases in Nasiriya City Al-Hussein Teaching Hospital, Thalassemia Center and the Central Blood Bank in Nasiriya Citysouthern of Iraq. for the period from the first period. From February 2022 until the end of February 2022, the average age of patients infected with chronic hepatitis B virus was 64.5 years, and the average age of healthy carriers of hepatitis B surface antigen was 35. 1 year, and the ratio of males to females was (12.2:) for chronic patients and (13.6:) for carriers of the disease. As for the deoxyribonucleic acid, it was (100%) in chronic patients and healthy carriers using the Nested type polymerase chain reaction, and at a rate of (30.0%) and (46.7%) in chronic patients and healthy carriers, respectively using the polymerase chain reaction technique. direct with a significant difference between the two interactions. The current results confirm that a nested PCR protocol to detect HBV DNA is a more sensitive way of detecting HBV in Iraq CHB patients and carriers. Recent advanced techniques such as nucleic acid assays, quantitative assays for viral load and RT-PCR for Iraqi viral hepatitis laboratories are recommended.</p> MushtaqTalib Al-Safi Copyright (c) 2024 2024-03-17 2024-03-17 36 40 10.37022/wjcmpr.v6i1.317 Current status of Rabies Prophylaxis in Dalaba (Republic of Guinea) <p><strong>Objective:</strong> Rabies is a real risk to public health, and remains a zoonosis with considerable medical and economic impact on both humans and animals. The aim of this study was to identify and evaluate rabies control measures applied in the urban township of Dalaba.</p> <p><strong>Materials&nbsp;&nbsp; and&nbsp;&nbsp; Methods:</strong> The methodology adopted was based on consultation of animal health managers and analysis of archives; field surveys of human health services, owner-managers of domestic carnivores and livestock breeders; and evaluation of anti-epizootic measures. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</p> <p><strong>Results:</strong> From 2010 to 2017, consultation of executives and analysis of archives revealed the following data: 25 reported cases of carnivore bites, of which 19 were observed by veterinary practitioners; 32 cases of clinical animal rabies recorded, including 18 dogs, 13 cattle and 1 cat; and 103 animal rabies vaccinations. A search of health facility consultation registers showed 400 cases of bites attributable to carnivores, of which 37 victims were subjected to post-exposure vaccination. From 112 carnivore owners surveyed, (50.89%) claimed to be perfectly aware of the disease. To prevent the disease, 14.28% have their animals caged; 22.32% vaccinate and 29.82% vaccinate regularly; 14.29% have their dogs castrated, and 31.25% feed their animals regularly. Among the 210 carnivores registered, 45 dogs (21.43%) and 2 cats (0.95%) have been vaccinated against rabies, giving a vaccination coverage rate of 22.38%.</p> <p><strong>Conclusion:</strong> At the end of this research, we noted that rabies constitutes a real threat and a major zoonosis requiring the adoption of strategies for better control.</p> Lanan Wassy Soromou Matho Sonomou Mohamed Keyra Copyright (c) 2024 2024-04-17 2024-04-17 41 46 10.37022/wjcmpr.v6i1.320 Role of vosoritide drug on children's with achondroplasia <p>Achondroplasia is a genetic condition with an autosomal dominant inheritance pattern. It is caused by detrimental heterozygous FGFR3 gene mutations. Gain-of-function mutations in the FGFR3 gene impair chondrocyte differentiation and proliferation, which has a negative impact on the formation of new bone. Vosoritide, also known as voxzogo, is the first pharmacological intervention to receive approval for the treatment of achondroplasia. This therapeutic agent has been sanctioned for administration via at-home injections, which are to be performed under the supervision of a proficient nurse.</p> Ahmed tawfeeq ahmed dr.inas hazim Nibras hazim hameed Copyright (c) 2024 dr.inas hazim 2024-02-21 2024-02-21 9 12 10.37022/wjcmpr.v6i1.311 A review of leishmania genome, hosts, virulence factors, pathogenesis and treatment <p>The study aims in this review to study the <em>Leishmania</em> genus parasite that causes Leishmaniasis, in its clinical forms Cutaneous Leishmaniasis (CL), MucocutanousLeishmaniasis (ML) and Visceral Leishmaniasis (VL). When studying the parasite's genetic composition of the genome of the nucleus and the genome of the kinetoplast, which constitutes 10-20% of the total DNA, it was found that despite the difference in pathogenicity between the types of the parasite <em>L.</em>, the genetic material is similar and maintains the genetic content. CL is a self-healing disease, but prompt treatment is important to avoid unattractive scarring and parasite spread. Of all the drugs of choice, Pentostam and Glucantime are the first line of treatment for all types of leishmaniasis, but there are serious attempts to discover new therapies.</p> Abdul–Jaleel Aziz KarimAlqaraghli Copyright (c) 2024 2024-03-16 2024-03-16 17 25 10.37022/wjcmpr.v6i1.315 A review of entamoebahistolytica genome, virulence factors, phylogenetic tree and treatment <p>The study in this review aims to know and study the parasite <em>Entamoebahistolytica</em> that causes Amoebiasis worldwide. During its life cycle, <em>E. histolytica</em> passes through several phases, trophozoite stage, precyst stage, the cyst stage, the Metacyst stage, and Metacystictrophozoite stage. In this study, the spread of the parasite globally and in the Arab world and methods of treating the disease were also discussed. The Genomic structureof <em>E. histolytica</em>, like other organisms, is characterized by diversity and heterogeneity in its genetic content, which is one of the most important reasons for its survival and its ability to infect. Interestingly, the genome of the <em>E. histolytica</em> contains a large amount of genes presumed to be of bacterial origin. The study of the genetic diversity of <em>E. histolytica</em> gives paths to the developmental change that resulted in the emergence of evolutionary features or traits. Understanding amoebic virulence is important. Several studies have shown that genetic factors influence the virulence of parasitic infections. Studying the virulence of <em>E. histolytica</em> by Serine-rich protein (REHP) gene is among the important issues used in molecular epidemiological studies.</p> Hind Abdulzahra Abdulkadhim Alshaibani Copyright (c) 2024 2024-03-17 2024-03-17 26 35 10.37022/wjcmpr.v6i1.316 A Case report on subdural hematoma in a 60yr old male patient with ESRD <p>A subdural hematoma occurs when a clot&nbsp; forms between the brain and its outer covering. Chronic dialysis becomes necessary as a treatment to externally filter the blood, when kidneys are no capable of fulfilling this role. This validates that the patients undergoing hemodialysis face a higher risk of developing subdural hematoma. The KDIGO foundation guidelines&nbsp; defines the chronic kidney disease using the markers such as the proteinuria and the glomerular filtration rate(GFR). Hemodialysis patient and other type&nbsp; of bleeding tendency are more prone to the spontaneous traumatic&nbsp; subdural hematoma and the intracerebral hematoma. This increased risk is attributed to the elevated mortality rate observed in the dialysis patient affected by the subdural hematoma. Consequently, it becomes imperative to implement the preventive measures aimed at reducing the occurrence of subdural hematoma in the individuals with the end stage renal disease, especially those undergoing the hemodialysis treatment. The high occurrence rate of the subdural hematoma and its recent surge is related to the increased use of anticoagulant in the long-term hemodialysis patient. Hence proper care for the patient is necessary to prevent devastating the disorder. This case report is demonstrating that there is a striking enrichment for the underlying comorbid conditions in the patient who has developed subdural hematoma and has the high risk of the immediate mortality.</p> Sunanda K Bhargava Narendra J Copyright (c) 2024 2024-03-16 2024-03-16 13 16 10.37022/wjcmpr.v6i1.314