World Journal of Current Medical and Pharmaceutical Research <p><strong>World Journal of Current Medical and Pharmaceutical Research </strong>(WJCMPR) is a double-blind peer-reviewed bimonthly open access international journal dedicated to the promotion of research in health and Pharmaceutical sciences. We define Open Access-journals as journals that use a funding model that does not charge readers. The journal publishes Research articles, Review article, Case studies and Short communication from broad areas like Medicine, Dentistry, Pharmacy, Anatomy, Physiology, Biochemistry, Neurology, Surgery, Orthopedics, Ophthalmol</p> World Journal of Current Medical and Pharmaceutical Research en-US World Journal of Current Medical and Pharmaceutical Research 2582-0222 <h4>Authors who publish with this journal agree to the following terms:</h4> <ol type="a"> <li class="show">Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a&nbsp;<a href="" target="_blank" rel="noopener">Creative Commons Attribution-NonCommercial 3.0 Unported License</a>. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.</li> <li class="show">Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.</li> <li class="show">Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See&nbsp;<a href="" target="_new">The Effect of Open Access</a>).</li> </ol> A TOTAL SURVEY ON LEAVES OF MELALEUCA ALTERNIFOLIA (TEA TREE OIL) <p>Tea tree oil, a basic oil extricated from the leaves of Melaleuca alternifolia by steam refining, supercritical liquid extraction, soxhlet extraction followed by progressive extraction and small scale stove extraction forms by various solvents has discovered a wide scope of antimicrobial exercises as antiviral, antifungal, antibacterial, against protozoval because of the nearness of terpinen–4-ol as the significant constituent. TTO was contain flavonoids, glycosides, quinolines, starches and so forth. TTO is considered and the rate yield of tea tree oil extricated is resolved and the piece of tea tree absolutes (terpinen-4-ol, 1,8-cineole, γ-terpinene and α-terpineol) separated was contrasted and standard tea tree oil just as with ISO 4730 TTO has discovered the mitigating and hostile to skin break out vulgaris, Psoriasis, free radical rummaging exercises. Tea tree oil is normal items, so it is non-harmful, effectively available, biodegradable, and biocompatible. The few points of interest of tea tree oil make it one of the gainful item having helpful impacts. The current audit article depends on the use of tea tree oil, extraction procedure of tea tree oil, constituents, security contemplations and so on.</p> Sankara Malathi Sidde Lahari Konapalli Rajani Mahalakshmi Sampagavi Mahalakshmi Sampagavi M.Sushma M.Sushma Copyright (c) 2020 2020-08-31 2020-08-31 271 279 10.37022/ A PROSPECTIVE OBSERVATIONAL STUDY ON THE EVALUATION OF RISK FACTORS IN PATIENTS DIAGNOSED WITH CORONARY ARTERY DISEASE IN TERTIARY CARE HOSPITAL. <p><strong>Background:</strong> coronary artery disease is one of the most common types of cardiovascular disorder and it occurs when the coronary artery that supply blood to the heart muscle is compromised due to the accumulation of materials such as plaque/cholesterol atherosclerosis risk factors associated with coronary artery disease&nbsp;&nbsp; men are susceptible at 45, women at 55 include age, gender, genetics, etc,</p> <p><strong>Objective: </strong>To identify the patients at elevated risk for CAD, To identify patients required further investigation to confirm the diagnosis of CAD, To describe a management plan including lifestyle changes, medications, psychosocial support, cardiac rehabilitation, etc.</p> <p><strong>Methods:&nbsp; </strong>A prospective observational study was conducted for a period of 6 months, from CAD patients attending max cure hospital. The data was collected from the participants after consent. Relevant patient lifestyles and lab data were documented in the data collection form (DCF).</p> <p><strong>Results: </strong>The study findings are according to parameter wise, age categorization defines that in 51-60 ranging age group 27.22% that is the highest percent affected people are observed with CAD.&nbsp; Of the total number of subjects participated in the study (n=202) the gender-wise comparison males (144) are more than females (58).To observe patient region, urban people (68%) are mostly affected with CAD than rural people (32%). To identify risk factors of CAD, patients with DM (34.67%), HTN (23%), smoking (17.32%), alcohol (25.74%), and obesity (13.86%) are the major risk factors associated with CAD. Based on family history a total of 21 members were identified out of 202, among them with CAD were 7, with CKD were 6, with HTN were 5 and with DM were 3 members respectively. &nbsp;According to the past history in a total of 202 members, patients with Cerebrovascular accidents were 4, patients with MI/UA were 20, and CKD were 4 respectively.</p> <p><strong>Conclusion: </strong>Evaluation of risk factors in patients with coronary artery disease in a tertiary care hospital was observed. Age, Diabetes mellitus, Hypertension, Smoking, Alcohol, and Obesity are more causing risk factors than others.</p> CHINMAYI PINNA Dharavath Vinay Naik Dharavath Vinay Naik Naresh Podugu Naresh Podugu Shaik.Mohammed Shaabaaz Shaik.Mohammed Shaabaaz Okeke Chukwugoziem Bright Okeke Chukwugoziem Bright Copyright (c) 2020 CHINMAYI PINNA, Dharavath Vinay Naik Dharavath Vinay Naik, Naresh Podugu Naresh Podugu, Shaik.Mohammed Shaabaaz Shaik.Mohammed Shaabaaz, Okeke Chukwugoziem Bright Okeke Chukwugoziem Bright 2020-09-01 2020-09-01 283 286 10.37022/ A RANDOMIZED DOUBLE BLIND PLACEBO CONTROLLED TRIAL OF GUATTERIA GAUMERI MOTHER TINCTURE IN THE MANAGEMENT OF HYPERLIPIDEMIA <p>Aim: Guatteria gaumeri has antioxidant, anti-inflammatory, and anti-diabetic activities. In the present randomized double-blind placebo-controlled trial is the efficacy of guatteria gaumeri mother tincture in hyperlipidemia. Hyperlipidemia patients meeting the inclusion criteria were randomly assigned to the treatment and placebo.</p> <p>Methods: 30 patients in the treatment group took guatteria gaumeri mother tincture; whereas the patients in the placebo group took placebo mother tincture for 12 weeks. The lipid profiles of the patients were evaluated at baseline, and after 6 and 12 weeks of the clinical trial.</p> <p>Results: The final results showed that guatteria gaumeri mother tincture significantly p-value 0.05 and improved LDL, HDL, cholesterol, compared to the placebo group. The guatteria gaumeri showed an inhibitory effect on hepatic enzymes and possible liver toxicity. No serious side effect was reported for guatteria gaumeri mother tincture administration. Therefore, guatteria gaumeri mother tincture could be considered as a supplement for the treatment of dyslipidemia.</p> Parveen Kumar Sharma Parveen Kumar Sharma Siva Rami Reddy E Siva Rami Reddy E Copyright (c) 2020 2020-09-05 2020-09-05 291 295 10.37022/ STUDY ON SAFETY OF INSULIN ADD ON THERAPY AND ORAL HYPOGLYCEMIC AGENTS (OHGAs) IN TYPE - II DIABETES PATIENTS <p><strong>Objectives:</strong> A clinical observational investigation directed to look at the security of Insulin add-on treatment and &nbsp;Hypoglycemic Agents in polypharmacy and to advance safe utilization of insulin and hypoglycemic agents in Type II Diabetes patients, through patient guiding by Clinical drug specialist at Jayabharath hospital, Nellore.</p> <p><strong>Methods:</strong> A Prospective Observational investigation was directed on Type -2 Diabetes mellitus patients in the General Medicine office in a tertiary consideration emergency clinic, during the time of June – December 2019. The work was completed by utilizing quiet information assortment structures and a Diabetes survey.</p> <p><strong>Results:</strong> Among 193 investigation populace with Type -2 Diabetes, hypoglycemic agents in polypharmacy 46.25% (n=108) was discovered to be more than Insulin alone, and Insulin add on treatment. Conclusion: From the examination, it was discovered that patients who are on hypoglycemic agents in polypharmacy were exposed to GI unsettling influences and who are on Insulin treatment was exposed to hypoglycemic scenes. Considering the key job of drug specialists the security of antidiabetic prescriptions and adherence was improved through patient directing.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</p> D.Ashalatha D.Ashalatha C.Roop kumar C.Roop kumar K.Prem Raj K.Prem Raj V.Vani V.Vani narayana swamy palyam Sankara Lakshmikanth Sankara Lakshmikanth Copyright (c) 2020 D.Ashalatha D.Ashalatha, C.Roop kumar C.Roop kumar, K.Prem Raj K.Prem Raj, V.Vani V.Vani, narayana swamy palyam, Sankara Lakshmikanth Sankara Lakshmikanth 2020-09-09 2020-09-09 301 306 10.37022/ Hand sanitizers: is over usage harmful ? <p>Sanitizers are the substances or the fluid designated to kill germs on skin and objects. As hand hygiene plays an important role in pandemic situations like COVID-19, people mostly rely on hand sanitizers than soap and water. The sanitizing effect of sanitizer depends on the ingredients such as 60-95% v/v alcohol, antiseptics, etc. The alcohol usually damages the skin by denaturation of stratum corneum proteins. The repeated or frequent use of hand sanitizers can cause skin reactions- Irritant contact dermatitis and Allergic contact dermatitis with symptoms such as burning, irritation, itching, etc. These effects can be reduced by using selected less irritating products, reducing skin irritation, use of moisturizing skin products. As microbial flora also plays an important role in human health, sanitizer overuse creates an imbalance between the good and bad bacteria in the digestive system which leads to inflammatory bowel diseases, obesity, autism, etc. As a researcher reported that sanitizer also gives an unpleasant side effect of using hand sanitizer every day and also mentioned that ‘we have to balance the benefit of sanitizer for preventing disease transmission and their potential misuse remains a challenge’.</p> Chandanapalli Sai Himabindu Chandanapalli Sai Himabindu Bitra Tanish Bitra Tanish Damodara Padma priya Damodara Padma priya Nimmala Prema Kumari Nimmala Prema Kumari Shaik Nayab Shaik Nayab Copyright (c) 2020 2020-09-09 2020-09-09 296 300 10.37022/ Case report on chronic liver disease with portal hypertension with massive ascites <p>Portal hypertension is an increase in the blood pressure within the system of veins called the Hepatic portal venous system. Veins coming from the stomach, intestine, spleen, and pancreas merge into the portal vein, which then branches into smaller vessels and travels through the liver. If the vessels in the liver are blocked due to liver damage, blood cannot flow properly through the liver. As a result, high pressure in the portal system develops. This increased pressure in the portal vein may lead to the development of large, swollen veins (varices) within the esophagus, stomach, rectum, or umbilical area (belly button). Varices can rupture and bleed, resulting in potentially life-threatening complications. We present a case of portal hypertension with massive ascites- A 43-year-old female was admitted with chief complaints of abdominal distension, abdominal pain, and shortness of breath prior to 15 days of presentation and the symptoms were gradually progressive in nature. Her past medical history reveals she had similar complaints in the past and known cases of chronic liver disease. After admission, she has been diagnosed with portal hypertension along with Refractory ascites. The management included antihypertensives and human albumin, A high protein diet with salt and fluid restrictions, large-volume paracentesis procedure was carried out daily.</p> Eunice Pala Eunice Pala N.Navya Anusha N.Navya Anusha J.Bhargava Narendra J.Bhargava Narendra Copyright (c) 2020 2020-08-31 2020-08-31 280 282 10.37022/ Case Report on Ulcerative Colitis in 16 year girl <p>Ulcerative colitis (UC) is a chronic idiopathic inflammatory disorder that involves any part of the colon starting in the rectum in a continuous fashion presenting typically with symptoms such as bloody diarrhea, abdominal pain, and rectal urgency.The clinical presentation of the disease usually dictates the choice of pharmacologic therapy, where the goal is to first induce remission and then maintain a corticosteroid-free remission. UC is diagnosed based on clinical presentation and endoscopic evidence of inflammation in the colon starting in the rectum and extending proximally in the colon. The choice of treatment depends on severity, localization and the course of the disease. For proctitis, topical therapy with 5-aminosalicylic acid (5-ASA) compounds is used. More extensive or severe disease should be treated with oral and local 5-ASA compounds and corticosteroids to induce remission. Patients who do not respond to this treatment require hospitalization. Intravenous steroids or, when refractory, calcineurin inhibitors (cyclosporine, tacrolimus), tumor necrosis factor-α antibodies (infliximab) or immunomodulators (azathioprine, 6-mercaptopurine) are then called for. Indications for emergency surgery include refractory toxic megacolon, perforation, and continuous severe colorectal bleeding.</p> MD.Salma MD.Salma Y.Siva Y.Siva , J.Bhargava Narendra , J.Bhargava Narendra Copyright (c) 2020 2020-09-02 2020-09-02 287 290 10.37022/