World Journal of Current Medical and Pharmaceutical Research https://wjcmpr.com/index.php/journal <p><strong>World Journal of Current Medical and Pharmaceutical Research </strong>(World Journal of Current Med and Pharm Research) is a double-blind peer-reviewed bimonthly open access international journal dedicated to the promotion of research in health and Pharmaceutical sciences. We define Open Access-journals as journals that use a funding model that does not charge readers for their institutions for access. The journal publishes Research articles, Review article, Case studies and Short communication from broad areas like Medicine, Dentistry, Pharmacy, Anatomy, Physiology, Biochemistry, Neurology, Surgery, Orthopedics, Ophthalmol</p> World Journal of Current Medical and Pharmaceutical Research en-US World Journal of Current Medical and Pharmaceutical Research 2582-0222 Identification, assessment and reporting of suspected Adverse Drug Reactions (ADRs) to Anti-retroviral therapy (ART) and Anti-tubercular therapy (ATT) in a community care centre at Warangal https://wjcmpr.com/index.php/journal/article/view/60 <p>Adverse effects of drugs are the main source of morbidity and mortality among the outpatients and inpatients. The objective of the study was to identify, assess and report suspected Adverse Drug Reactions in patients who are diagnosed with Human Immunodeficiency Virus-Acquired Immunodeficiency Syndrome (HIV-AIDS) patients with and without tuberculosis (TB). This was a prospective observational study conducted for a period of six months to explore the significant ADRs caused by Anti-Retroviral and Anti-Tubercular drugs in patients visiting the community care center at Warangal who are diagnosed with HIV-AIDS with or without Tuberculosis as co-infection. In our study, we enrolled 144 patients and a total of 514 ADRs were identified in 125 patients. The most common ADR observed in our study was peripheral neuropathy in 61 patients, followed by vomitings, weakness, anorexia, myalgia, diarrhea, and itching. The ART regimen Stavudine+Lamivudine+Efavirenz (STV+LMV+EFV) was found to be most commonly involved in about 138 ADRs, whereas the regimen Zidovudine+Lamivudine+Nevirapine (ZDV+LMV+NVP) was found to be having the least incidence rate of ADRs. Causality assessment was made using the WHO probability scale and Naranjo’s Scale and 340 (66.14%) and 346 (67.31%) ADRs were classified into Possible respectively. The severity of ADRs were assessed using Hartwig scale and 376 (67.50%) ADRs were classified into Moderate and 138 (26.84%) into Mild ADRs. The findings of our study showed that a huge number of ADRs were experienced by the patients who are receiving ART and ATT which is a major cause for medication Non-compliance and discontinuation of the therapy. Therefore, close monitoring and reporting of ADRs are needed in these patients who are receiving ART and ATT.</p> S.Arun Kumar K Kranthi Yarlagadda Feroz Wasim Copyright (c) 2019 2019-12-31 2019-12-31 209 215 10.37022/WJCMPR.2019.01064 Review on Blepharospasam https://wjcmpr.com/index.php/journal/article/view/61 <p>Blepharospasm is any abnormal contraction or twitch of the eyelid. the condition should be distinguished from the more common, and milder, Involuntaryquivering of an eyelid, known as myokymia. Benign essential blepharospasm (BEB) is craniofacial dyskinesia characterized by repeated, involuntary contractions of the orbicularisoculi, procerus, and corrugator muscles. The mechanism underlying benign essential blepharospasm is not yet clearly understood but is thought to be multifactorial, with a likely genetic component and an environmental trigger. It has been suggested that BEB may be partly due to abnormalities in the basal ganglia and dopaminergic system involving a subclinical loss of striatal dopamine.</p> Sowmya B Sharon Roja Ch Dr.Brahma Reddy Sravanthi K Copyright (c) 2019 2019-12-31 2019-12-31 200 202 10.37022/WJCMPR.2019.01062 A Review on Herbal Drug Therapy for Diabetes Mellitus https://wjcmpr.com/index.php/journal/article/view/62 <p>This review focuses on the study of herbal drugs used in Diabetes mellitus treatment. Diabetes mellitus becomes a common metabolic disorder that poses a serious threat to the world's public health. Approximately 60 percent of the world's population use traditional medicines derived from medicinal plants. Due to lower side effects and low cost, herbal formulations are favored. Synonymous with herbal medicine, phytomedicine or botanical medicine, plants are used for medicinal purposes. Herbal selection may depend on a number of factors, including the stage of diabetes progression, the types of comorbidities that patients have, availability, affordability, and herbal safety profile. A list is compiled of medicinal plants with proven antidiabetic and related beneficial effects and herbal medicines used in diabetes treatment.</p> Girija Dandu Venkateswara Reddy Basu Chaitanya P Rajesh D Suresh babu Suresh babu Anusha Bai R Copyright (c) 2019 2019-12-31 2019-12-31 203 208 10.37022/WJCMPR.2019.01063 A REVIEW ON CHEMOTHERAPY INDUCED COMPLICATIONS IN CANCER PATIENTS https://wjcmpr.com/index.php/journal/article/view/63 <p>Even with the evolution of chemotherapeutic procedures and agents, chemotherapy may cause certain side effects that impair the patients’ quality of life. The aim of this review is to isolate and describe the side effects arising only from chemotherapy. This paper comprises an extensive review of the main side effects affecting the health status of patients undergoing chemotherapy procedures. In addition, Cancer patients experience a variety of symptoms that can be physical or psychological. These symptoms may vary in terms of occurrence, severity, and distress and can be the result of the illness or the treatment.</p> Vijaya Madhavi A `Rama Brahma Reddy D Sai Basha D Hussain Sk Shaheda Afreen Sk Haritha S Copyright (c) 2019 2019-12-31 2019-12-31 216 222 10.37022/WJCMPR.2019.01065 An Overview of Crimean Congo Hemorrhagic Fever https://wjcmpr.com/index.php/journal/article/view/64 <p>Crimean Congo hemorrhagic fever (CCHF) is a zoonotic disease. It is caused by an RNA virus in wild and domestic mammals, birds and ticks. It is the family of Bunyaviridae from the Arbovirus group. The main vector and reservoir of the CCHF virus are hard-body ticks principally of the <em>Hyalomma</em>genus. The Hyalomma tick bite infection has the highest rate of nosocomial transmission especially due to direct human to human contact. India reported its first CCHF case in the year 2011 from Ahmadabad, Gujarat. Since then, several sporadic cases and outbreaks of CCHF have been reported the most from Gujarat and few from Rajasthan and the Uttar Pradesh States of India. Animals do not show clinical signs but may act as a source of infection for humans. The virus is transmitted from animals to humans either by direct contact with the blood or tissue of infected animals. Laboratory tests used to diagnose CCHF include reverse transcriptase (RT)-PCR, immunofluorescence assay (IFA), antibody (IgG, IgM) and antigen-capture ELISA, and isolation of the virus. Ribavirin acts as an effective anti-viral agent against CCHFV by inhibiting its replication. Supportive therapy including the administration of erythrocytes, thrombocytes, and fresh frozen plasma acts as an important strategy to control CCHF at an early stage.</p> SAIKIRAN JAKKULA Santhosh Nallagasha Rohith Kumar Kadarla Copyright (c) 2019 2019-12-31 2019-12-31 223 226 10.37022/WJCMPR.2019.01066 AN OVERVIEW ON EXTRACTION TECHNIQUES OF BIOACTIVE PHYTOCEUTICALS- PLAI PLANT https://wjcmpr.com/index.php/journal/article/view/65 <p>Medicinal plants are gaining more importance these days as it can provide better treatment alternative for many common diseases with less side effects. One such herbPlai- Zingibercassumunar of Zingiberaceae family proved to have many pharmacological actions like anti-inflammatory, anti-microbial, cytotoxic etc. Various extraction methods for its rhizomes are getting more interest as it constitutes numerous photochemical constituents to elicit various actions. Any studies on medicinal plants start with their extraction methods and thus different types of extraction methods are available today. Hence this review focus on comparison of most common extraction methods for various active constituents from rhizomes of Zingiber cassumunar.</p> ``Baby Sini Jose Dimal Agnes K Mathew John Biniya Antony Varghese Antony Copyright (c) 2019 2019-12-31 2019-12-31 227 229 10.37022/WJCMPR.2019.01067 A Review on Pharmacological Activities of Alkaloids https://wjcmpr.com/index.php/journal/article/view/66 <p>Alkaloids are a category of molecules in nature around the globe with a relatively large occurrence. These are chemicals and biomolecules that are very complex. Alkaloids are compounds of a very diverse class of secondary plant metabolites; alkaloids, such as anticholinergics, antitumor, diuretic, antiviral, antihypertensive, antiulcer, analgesic, and anti-inflammatory, have been linked to the extensive list of biological activities. The basic character of alkaloids allows salts to be formed with mineral acids or organic acids, alkaloid salts are usually soluble in water and dilute alcohols, and are not soluble in organic solvents except in rare cases. This research is carried out mainly in the context and classification of alkaloids and alkaloids pharmacological practices.</p> Sireesha Badri Venkateswara Reddy Basu Khadar Basha S Chandra K Anasuya D Copyright (c) 2019 2019-12-31 2019-12-31 230 234 10.37022/WJCMPR.2019.01068 CASE REPORT ON SEIZURE WITH CO ADMINISTRATION OF LEVOFLOXACIN AND THEOPHYLINE https://wjcmpr.com/index.php/journal/article/view/56 <p>Case Summary: An 84-year-old man was admitted to the hospital due to seizure episodes. One week before the patient was admitted to the same hospital with complaints of COPD exacerbation and was discharged with a prescription of levofloxacin, theophylline ceftriaxone, pantaprazole, montelukast, methylprednisolone, budesonide nebulization, ipratropium bromide nebulization, and syrup codylex. After receiving one dose of oral levofloxacin, the patient experienced a seizure. The patient was hyperglycaemic at the time of admission and had no history of a seizure disorder. Discussion: Here the cause of seizure could be a drug-drug interaction (between theophylline and levofloxacin) with CYP1A2 substrates with no epileptogenic effects which could augment the concentration of levofloxacin and consequently results in seizures. In spite of that, it has to be kept in mind that the drug-drug interactions originate at various pharmacodynamic and pharmacokinetic levels and that drugs CYP affinities are rarely completely CYP-specific. Thus levofloxacin may have drug interactions at the level of CYPs other than CYP1A2. Conclusion: the clinicians are advised to closely monitor the possibility of seizures in COPD patients who+ are taking both levofloxacin and theophylline. The physicians should also be encouraged to use the techniques of TDM to individualize the dose of narrow therapeutic drugs to avoid serious adverse effects.</p> Neethu Mariyam Johny Aby Paul Swapna Saju Dona Johnson Jobin Kunjumon Vilapurathu Copyright (c) 2020-01-15 2020-01-15 198 199 10.37022/WJCMPR.2019.01061