World Journal of Current Medical and Pharmaceutical Research <p><strong>World Journal of Current Medical and Pharmaceutical Research </strong>(WJCMPR) is a double-blind peer-reviewed bimonthly open access international journal dedicated to the promotion of research in health and Pharmaceutical sciences. We define Open Access-journals as journals that use a funding model that does not charge readers. The journal publishes Research articles, Review article, Case studies and Short communication from broad areas like Medicine, Dentistry, Pharmacy, Anatomy, Physiology, Biochemistry, Neurology, Surgery, Orthopedics, Ophthalmol</p> World Journal of Current Medical and Pharmaceutical Research en-US World Journal of Current Medical and Pharmaceutical Research 2582-0222 <h2><span style="font-size: 14px;">Copyright © Author(s) retain the copyright of this article.</span></h2> ROLE OF STRESS ECHOCARDIOGRAPHY IN THE FUNCTIONAL ASSESSEMENT OF PROSTHETIC MITRAL VALVE <p style="margin: 0cm; margin-bottom: .0001pt;"><strong>Objective:&nbsp;</strong>To assess the resting echo profile of patients with prosthetic mitral valve and monitor the function of the prosthetic valves by doing stress echocardiography by treadmill exercise and dobutamine infusion.</p> <p style="margin: 0cm; margin-bottom: .0001pt;"><strong>Methods</strong>:&nbsp;An open-labeled prospective randomized comparative study was conducted in &nbsp;30 patients at Madras Medical&nbsp; College and Hospital, Chennai- 600 003, Tamil Nadu. Patients, who have been done mitral valve replacement, were selected randomly to undergo the stress echocardiography. 14 male and 16 female patients were included and evaluated on the basis of Echocardiographic examination, Exercise studies, Dobutamine stress echocardiography &amp; Estimation of LV outflow.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</p> <p style="margin: 0cm; margin-bottom: .0001pt;"><strong>Results: </strong>Upon comparison, the patient's heart rate were increased from rest to exercise by a mean of 24 ±12.5 beats per minute. The paired t-test showed a significant correlation with an increase in the dobutamine group (P &lt;0.001). With respect to peak gradients, it was increased between the two stress protocols was statistically significant (P &lt;0.001). The mean gradient obtained at rest and with exercise and dobutamine stress also showed a similar pattern of increase as seen in the peak gradient. Moreover,&nbsp; the net difference in the Pulmonary artery pressure achieved with both stress protocols was 5.563±4.6mmHg more in the exercise protocol which was statistically significant&nbsp; (P &lt;0.001).</p> <p style="margin: 0cm; margin-bottom: .0001pt;"><strong>Conclusion:&nbsp;</strong>The study reveals Dobutamine produces a greater augmentation in the effective mitral orifice area when compared to exercise. Similarly, the exercise protocol produces a much higher increase in the pressure gradients when compared with dobutamine.</p> Dr.P.S.CHAKKARAVARTHI Copyright (c) 2021 2021-04-08 2021-04-08 13 20 10.37022/ ALOE VERA AND ITS BIOLOGICAL ACTIVITIES <p>Aloe Vera is used for medicinal purposes since ancient times. The botanical name is Aloe barbadensis miller. It belongs to the Liliaceae family. It is also called the healing plant or the silent healer, because of its wound and burn healing properties. Latex and gel are the two basic products of Aloe leaves. The latex and gel contain biologically active components. Polysaccharides contained in the gel of the leaf attribute most of the health benefits associated with Aloe Vera. Aloe was available as pills, ointments, jellies, sprays, drinks, etc. The important application aloe Vera was wound healing, treating burns, anti-inflammatory, antidiabetic, anti-cancer, anti-ulcer, protection against skin damage from x-rays, lung cancer, intestinal problems, increasing HDL, reducing LDL, reducing blood glucose in diabetics, fighting against acquired immune deficiency (AIDS), allergies, etc. The aloe Vera plant, its biological properties are briefly reviewed in this article.</p> <p>&nbsp;</p> <p>&nbsp;</p> Elseena Jose Shilpa Joseph Mariya Joy Copyright (c) 2021 SHILPA JOSEPH 2021-04-16 2021-04-16 21 26 10.37022/ A Brief Review on Breast cancer treatment and current challenges <p>Cancer is a global disease, so rational and effective treatment is needed. Breast cancer is one of the most common cancers in a woman and now the number of patients is increasing day by day. Therefore, development and research are underway for the effective treatment of breast cancer. Breast cancer treatment depends on the stage of cancer and the risk, based on this medical agents should be employed on patients to prevent breast cancer. In addition, breast cancer survival rates are rising which is good news for science but on the other hand the side effects of treatment present new challenges. An early-stage cancer diagnosis can save a patient's active or healthy life due to long-term and varied treatments that can be used for cancer otherwise breast cancer is a life-threatening disease. Breast cancer survivors not only have negative side effects of cancer treatment but also, have many other issues of previous treatment so it is a challenge for researchers. As a result, this review article deals with the effective treatment of breast cancer and its side effects. This review will help researchers better understand the long-term medical implications for breast cancer.</p> Isha Shah Nensi Raytthatha Copyright (c) 2021 2021-04-18 2021-04-18 27 31 10.37022/