World Journal of Current Medical and Pharmaceutical Research

Insilico pharmacological evaluation of dibenzosuberenone derivatives as antidepressant

Sathishkumar A — 2023-03-12

A new drug takes a long time and is expensive to introduce.By using insilico drug design, you can save time and money. Utilizing computational software, a novel Schiff's base Dibenzosuberenone derivative was designed and molecular docking studies were performed using autodock software. To predict Absorption, Distribution, Metabolism, Excretion, and Molecular Properties of Dibenzosuberenone derivatives, insilico screening was performed. It should be examined how its Dibenzosuberenone derivatives interact with specific targets. The Dibenzosuberenone derivatives were successfully identified as targets in this study.

A herbo health care for gums and throat

Naveena N — 2023-03-14

The use of herbal gum paint in the treatment of dental problems is not very common. Most of the drugs used are synthetic and are in used over the years mainly for antibacterial activity in the oral cavity. It includes various side effects that are always a limit for their use. Natural remedies are always more desirable and acceptable and are more effective with fewer side effects. ThemicroorganismincludesEscherichiacoli, Klebsiella pneumonia, Staphylococcusepidermidis, and staphylococcus aureus which causegingivitisanddent cavities. The current study objective is to formulate and evaluate an herbal gum paint that is useful in the long term and has rheological characteristics and stability too. The local anesthetic activity is studied and the antimicrobial activity of gum paint is examined by disc diffusion method and compared activity between F1-betel leaf oil, F2- clove oil, and an F3 (F1+F2) – both betel leaf and clove oil. F3 shows a synergistic effect on microbes than the other two and has the maximum zone of inhibition.

Case report of drug induce erythroderma in diabetic patient

Suberna Basnet — 2023-03-03

Erythroderma, a severe form of skin reddening, is often difficult to diagnose and is usually caused by underlying inflammatory skin conditions. In this case report, we present the management of a patient diagnosed with drug-induced erythroderma. The patient developed generalized redness and scaling 21 days after receiving an unknown injection for pain from a local pharmacy. A thorough history and clinical examination were conducted, and drug-induced erythroderma was suspected. The patient was treated with a combination of mid-potency corticosteroids, liquid paraffin, recombinant human epidermal growth factor, and oral antihistamines. The patient recovered after strict diabetic diet control and was discharged

Diabetic ketoacidosis associated seizures: a case report

Sakeena Kaukab Khan — 2023-03-11

Diabetic ketoacidosis is the complicationof Diabetes mellitus, which can result due to extreme hyperglycemia and ketonaemia. This condition is prevalent among patients with untreated diabetes ordrug incompliance. Hyperglycemic hyperosmolar state can clinically be presented with episodes of seizures with high blood sugar levels and absence of ketones and has low incidence rate. A 55 year old male patient presented with episode of seizure, frothing, tongue bite, uprolling of eyes, shortness of breath, pedal edema and high blood sugar levels. Past medical history includes known hypertensive and diabetic since 10 years and is oninj regular insulin with non-adherence to medication. Lab investigations were performed and patient was diagnosed as hyperglycemic diabetic ketoacidosis secondary to drug incompliance. The patient was managed by insulin regimen- regular and basal insulin, antibiotics, antiepileptic drugs and by continuous monitoring of blood sugar levels every 3^rd hourly. Diabetic ketoacidosis was recovered and later, there were no episodes of seizures. Creating awareness and proper patient education regarding the disease state, pharmacotherapy and drug compliance plays a vital role in managing the condition and as well as by preventing further complications that might be fatal in some cases.