World Journal of Current Medical and Pharmaceutical Research <p><strong>World Journal of Current Medical and Pharmaceutical Research </strong>(WJCMPR) is a double-blind peer-reviewed bimonthly open access international journal dedicated to the promotion of research in health and Pharmaceutical sciences. We define Open Access-journals as journals that use a funding model that does not charge readers. The journal publishes Research articles, Review article, Case studies and Short communication from broad areas like Medicine, Dentistry, Pharmacy, Anatomy, Physiology, Biochemistry, Neurology, Surgery, Orthopedics, Ophthalmol</p> World Journal of Current Medical and Pharmaceutical Research en-US World Journal of Current Medical and Pharmaceutical Research 2582-0222 <h2><span style="font-size: 14px;">Copyright © Author(s) retain the copyright of this article.</span></h2> A STUDY ON THE EFFECT OF EXACERBATIONS ON THE QUALITY OF LIFE OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE <p><strong>Aim:&nbsp; </strong>The main aim of this study is to evaluate the effect of exacerbations on the quality of life of the patients with chronic obstructive pulmonary disease.</p> <p><strong>Materials and Methods: </strong>Patients of both the genders and with an age of above 18 years of patients who were diagnosed with COPD were included in this prospective study. Modified British Medical Research Council (m-MRC) Dyspnoea Scale was used to establish functional impairment due to shortness of breath in the study participants. Saint George's Respiratory Questionnaire (SGRQ) was also used to assess the patient’s overall health and quality of life-based on self-report.</p> <p><strong>Results:</strong> Among the 110 study participants, 87.3% were males and 12.7% were females. It was observed that majority of the patients were in the age group 51-60 years (43.6%). The most frequently observed co-morbidities were hypertension (22.7%) followed by diabetes mellitus (19.1%). Most of the patients were observed to be with m-MRC grade-3 (42.7%) followed by m-MRC garde-2 (39.1%). The SGRQ score was observed to be increased with increase in the frequency of exacerbations.</p> <p><strong>Conclusion: </strong>Clinical Pharmacist should take the responsibility in providing effective evidence based therapeutic recommendations for the better management and well being of the COPD patients.</p> PUSHPAVALLI KOTHA Naga Vamsi Krishna Vasabhakthula Christine Undurthi Siva Ganga M Copyright (c) 2020 PUSHPAVALLI KOTHA, Naga Vamsi Krishna Vasabhakthula , Christine Undurthi, Siva Ganga M 2020-12-15 2020-12-15 319–321 319–321 10.37022/ Formulation and Evaluation of Orally Disintegrating Tablet of Metoclopramide Hydrochloride <p>Orally disintegrating drug delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the fastest, safest, convenient, and most economic method of drug delivery having the highest patient compliance and preferred over conventional tablets. The goal of this study was to formulate and evaluate oral disintegrating tablets (ODTs) of Metoclopramide hydrochloride to overcome swallowing difficulties. The key to developing successful ODT formulation by direct compression method is to select the right super disintegrant.&nbsp; Nine formulations were prepared using different super disintegrants such as sodium starch glycolate (SSG), croscarmellose sodium (CCS), and crospovidone (CP) at three concentrations i.e. 2.8 %, 4 %, and 4.8 %. The formulation was evaluate for pre and post-compression parameters like angle of repose, compressibility index, Hausner's ratio, uniformity of content, thickness, hardness, friability, drug content, wetting time, water absorption ratio, dispersion time, in-vitro disintegration time etc. Results revealed that among the 9 formulations, the formulation MHF9 containing 4.8 % of crospovidone was selected as the best formulation as its wetting time 28 second, disintegration and dispersion time 7 second and 18 seconds, percentage drug release after 15 minutes was 102.52 %.</p> Sujan Dawadi Bipindra Pandey Sabina Nepal Yamuna Gurau Rashmi Shahi Bijay Gautam Deepak Akauliya Manoj Pandit Sailendra Chaudhary Chandrika Adhikari Mahat Copyright (c) 2020 Sujan Dawadi, Bipindra Pandey Pandey, Sabina Nepal, Yamuna Gurau, Rashmi Shahi, Bijay Gautam, Deepak Akauliya, Manoj Pandit, Sailendra Chaudhary, Chandrika Adhikari Mahat 2020-12-15 2020-12-15 322 329 10.37022/