World Journal of Current Medical and Pharmaceutical Research 2020-03-06T10:47:57+0530 WJCMPR Open Journal Systems <p><strong>World Journal of Current Medical and Pharmaceutical Research </strong>(World Journal of Current Med and Pharm Research) is a double-blind peer-reviewed bimonthly open access international journal dedicated to the promotion of research in health and Pharmaceutical sciences. We define Open Access-journals as journals that use a funding model that does not charge readers. The journal publishes Research articles, Review article, Case studies and Short communication from broad areas like Medicine, Dentistry, Pharmacy, Anatomy, Physiology, Biochemistry, Neurology, Surgery, Orthopedics, Ophthalmol</p> Knowledge, Attitudes and Reported Practices of Dental Students in Omer-Almokhtar University Regarding Tobacco Effects on Oral Cavity Health 2020-03-03T23:31:31+0530 Halima A Ayyad Muna. R R Farag Farag Raga A Elzahaf Elzahaf <p>Background: Tobacco use is risk factor causes of preventable death in the world. Oral health professions provide multiple opportunities for interventions throughout their careers that could lessen tobacco correlated diseases. Three factors knowledge, attitudes and behaviour are thought to play a starring role in determining the extent of tobacco use between patients and help dental clinicians to implement smoking cessation policy. Present study aimed to determine dental student's level of knowledge, awareness and practice regarding tobacco use and students/ dentists’ role in tobacco cessation.Subjects and methods; A total of 160 students were recruited from Faculty of Dentistry, Omer- Almokhter university, and surveyed using an anonymous self administered questionnaire. This questionnaire was based on intensive literature review. Cross-section study design was applied using a structured questionnaire which included data related to personal characteristics and assessment of KAP of participants.Results: one hundred eight students responded with (82.4%) were females and 17.6 % were males. That majority of responding students had high level of knowledge attainment on tobacco with the exception of knowledge about smokeless tobacco which was inadequate. Although, most students (92.6%) agreed that dentist has an important role in tobacco control and training regarding tobacco effects is sufficient to allow them to help their patients to quit smoking, only 56.6% give advices to their patients. The prevalence of smokers among students was low (4%).Recommendation Education about tobacco effects necessity involved in the curriculum from first year. Students should be given training about smoking cessation and counselling techniques and must be motivated to play their role in patients’ education regarding smoking.</p> 2020-02-27T00:00:00+0530 Copyright (c) A Compartive Study of Dengue Verses Malaria in Tertiary Care Hospital versus Government Hospital 2020-03-03T23:44:03+0530 Rathna Kumari G Khavya Sri G Dr.Bhargava Narendra J <p>In an attempt we are assessing a clinical study, knowledge, awareness and preventive measures acknowledgment of Communicable Diseases such as Dengue and Malaria among patients in Tertiary Care Hospital Versus Government Hospital in Khammam, to compare the probability of communicable disease such as Dengue and Malaria in selected Hospital. To compare the prevalence of Dengue and Malaria among Urban and Rural people in selected hospitals. The present study was a multi-cantered prospective observational study conducted in Mamatha General Hospital and Khammam Government Hospital, Khammam, Telangana, India. The total number of cases collected during the study period 6 months was 500. A multi-centered prospective observational study. The major finding of this study is that the probability of Communicable diseases such as Malaria and Dengue among patients. In this study the population is 500, the highest Prevalence is Dengue i.e. 465(93%) than Malaria i.e. 35(7%). In these Female patients are high i.e. 252 compared to Male i.e. 248. According to study evaluation females are more affected. The occurrence of Dengue is observed in the Age group of 41-50 years i.e. 90 patients. The Rural group related patients i.e. 342 are more when compared to urban group related patients i.e. 158. The present multi-centered prospective observational study was conducted in subjects(n=500) from inpatients of Department of General Medicine, Mamatha General Hospital and Khammam Government Hospital, Khammam, Telangana, India, to assess the Probability of Malaria and Dengue, Knowledge assessment among patients about Malaria and Dengue, and also Acknowledging the patients about Dengue and Malaria.</p> 2020-02-27T00:00:00+0530 Copyright (c) A Study on Drug Utilization Pattern in Outpatient General Department 2020-03-03T23:55:06+0530 Rama Brahma Reddy D Prashanthi G Sowmya L Naga Sai R Jaya Surya V <p>Introduction: Drug utilization Review (DUR) also referred to be as drug utilization evaluation (DUE) and Drug utilization Pattern (DUP). It is defined as ongoing, authorized and systemic quality improvement process. WHO in 1977 defines drug utilization as “The marketing, distribution, prescription and use of drug in a society with special emphasis on resulting medical, social and economic consequences”. Drug utilization studies evaluate drug use at a population level, According to age, sex, social class. They provide feedback on drug utilization data to the prescribers. DUP Involves a comprehensive review of patient’s prescription and medication data before, during, and after dispensing to ensure appropriate medication decisions making and positive patient outcomes. Drug utilization pattern play a significant role in helping the healthcare system to understand, explain and improve the prescribing administration the use of medications. Pharmacokinetic and pharmacodynamics in general department differs in various age groups. The ultimate goal is to achieve rational and effective pharmaceutical care to the general department patients. This has resulted in a clarification of their uses, wider indications, and alternative methods of delivery. DU studies become one of the power full tools in evaluation of health system. Method: we conducted a single cantered observational and prospective analysis in general department patients age between 10-80 years at Sri sai niharika nursing home, old palnadu bus stand, narasaraopet. A total number of 1648 prescriptions were recorded. The drug data such as name of the drug, dosage-form, dosing frequency, route of administration were also noted. The results were presented as percentage. Conclusion: This study provides the information about the prescribing patterns of drug in general department patients. And conclude the role of clinical pharmacist is vital to be an integral part well as to clear the irrational use of drugs in general department. Pharmaceutical care is needed in the correct management of drugs which is even more important in case of general patients. The WHO core indicators helped to improvise the prescribing pattern, identify significant problems involved in the knowledge gap of patients or care takers understanding of instructions provided by consultants and even to minimize the cost burden on the patients.</p> 2020-02-27T00:00:00+0530 Copyright (c) A Descriptive Study on Adverse Reactions of Chemotherapy and Assessment of Knowledge Score in Cancer Patients 2020-03-04T00:00:06+0530 A Vijaya Madhavi A Rama Brahma Reddy D Sai Basha D Hussain Sk Shaheda Afreen SK Haritha S <p>Even with the evolution of chemotherapeutic procedures and agents, chemotherapy may cause certain side effects that impair the patient’s quality of life. The aim of this research was to isolate and describe the side effects arising only from chemotherapy. This paper comprises an extensive research of the main side effects affecting the health status of patients undergoing chemotherapy procedures. In addition, Cancer patients experience a variety of symptoms that can be physical or psychological. These symptoms may vary in terms of occurrence, severity and distress and can be the result of the illness or the treatment.</p> 2020-03-27T00:00:00+0530 Copyright (c) ASSESSMENT OF RISK FACTORS AND DRUG UTILIZATION PATTERN OF STROKE PATIENTS IN NEUROLOGY DEPARTMENT 2020-03-04T00:05:04+0530 Karishma Sk Rama Brahma Reddy D Narendra Kumar B Mahesh Babu K Swathi Sri K Sneha S <p>Stroke is the second leading cause of death behind heart diseases in 2013 and a major cause of permanent disability. The burden of stroke in terms of mortality, morbidity and disability is increasing across the world. Neuroprotective drugs has become the core treatment, Due to lack of awareness in people of hospitalization very soon after occurrence of symptoms leading to disability. So this study aimed to discuss in detail on risk factors of stroke and drug utilisation patterns to be followed to achieve rational drug use in effective treating and to prevent disability in stroke patients. The risk factors both modifiable and non modifiable risk factors and standard treatment guidelines for effective treatment in both Ischemic stroke and Hemorrhagic stroke were discussed in detail.<strong>Objectives:</strong>To study the drug prescribing pattern among stroke patients and the indications for which&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; they have prescribed. To determine the average drug encounter for prescription. To evaluate hazards, then remove or minimise its risk by adding control measures.&nbsp;<strong>Materials and Methodology:</strong>The current study was a prospective observational study of stroke patients to the department of neurology, Lalitha Super Specialities hospital Pvt Ltd, located in Guntur, Andhra Pradesh. The data collection for the study was conducted between September 2019 to January 2020. Data on demographic parameters, drug prescription pattern and clinical profile was documented.<strong>Results: </strong>&nbsp;There was high proportion of&nbsp; Ischemic strokes reported 81.61% than hemorrhagic stroke 18.39%. There were about 66.14% males affected when compared to 33.85% females. Mostly age group with 61-70 years were mostly affected in both the genders with 33.89% males and 26.49% females. The risk factor hypertension was reported as most prominent one with 80.26% and diabetes mellitus with 52.01% respectively. There was high proportion of Polypharmacy among the study was reported most of the prescriptions contain 8 drugs 21.28%. The most common category of drugs being consumed were antacids 11.30%, vitamins and supplements 11.28%,Nootropics 9.62%, Antihypertensives 9.52%, antiplatelets 9.305 and statins 8.93%.<strong>Conclusion: </strong>&nbsp;Prevention is better than cure early identification and management of&nbsp; risk factors like hypertension, diabetes mellitus and change in life style habits like smoking and alcohol consumption may reduce the risk of stroke. Proper prescribing pattern and monitoring the patients may prevent the ADR’s and drug interactions occurring in stroke patients. Follow up of the patient should be taken for the medication adherence and to prevent relapse. The people with good educational background had the awareness on early identification of stroke symptoms and it’s risk factors.</p> 2020-03-27T00:00:00+0530 Copyright (c) A Prospective Randomised Study on Prevalence and Awareness of Self Medication of Analgesics among Teritiary Care Hospital 2020-03-04T00:08:14+0530 Prudhvi V Sravani R Beulah D Anantha Ch <p>self- medication is described as obtaining and consuming one (or) more drugs or medications&nbsp;&nbsp; without the advice of physician either for diagnosis, prescription (or) surveillance of the treatment. The main aim of research is to estimate the prevalence of self- medication of analgesics among hospitalized patients along with causes of illness and symptoms that lead to self-medication. The study was conducted in a tertiary care hospital .a total sample of 226 subjects was investigated by using a self- questionnaire form .based on findings the prevalence of irrational use of analgesics are about 65%&nbsp; of females (n=144) and 37% of males (n=82).self -medication was more prevalent among age group above 45years in which female are in greater use. self -medication is most commonly used in participants who are having joint pains (51%), muscle pains (29%), head ache (28%), back pain (21%),.among them 21.26% are having confidence on knowledge about medication. During self -medication with analgesics patients stop taking medicine after symptoms disappeared(62.30%),a few days after recovery (13.11%),after completion of course (18.85%),after consulting doctor /pharmacist (4.92%).over use of analgesics causes kidney and heart problems .72.72%does not know causes and uses analgesics frequently of the total participants only 43.52%are in aware that pharmacist will explain about medication usage. This research is carried out mainly in the context to raise awareness of the dangers of self -medication of analgesics. There is need to aware public that pharmacist can explain about drugs, their side effects.</p> 2020-02-27T00:00:00+0530 Copyright (c) EVALUATION OF ETHANOLIC ROOT EXTRACT OF ALLIUM CEPA. L FOR ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES IN ANIMAL MODELS 2020-03-06T10:47:57+0530 Krupavaram B Kaashmeera Nair K Hanish Singh JC Anandarajagopal K Jaasminerjiit Kaur Shopana Paramasivam <p><strong>&nbsp;</strong>Objectives: This present study was envisaged to identify the effect of analgesic and anti-inflammatory activity forethanolic root extract of <em>A</em><em>llium cepa</em><em> L</em>.&nbsp;Methodology: The study was carried out using Sprague- Dawley rats (250- 300g) and Albino mice (25- 30g). Diclofenac sodium and Tramadol are the standard drugs, was prepared by dissolving in distilled water to make the concentration of 10mg/kg and 20mg/kg for anti-inflammatory and analgesic activity respectively. The effect of ethanolic extract of <em>A.cepa L</em> root was investigated for analgesic activity using tail immersion method. The anti-inflammatory activity of ethanolic root extract of <em>A.cepa</em> was studied using carrageenan-induced paw edema to the rats.Results: The anti-inflammatory activity was evaluated using carrageenan method in Sprague- Dawley rats. The anti-inflammatory activity was found to be dose dependent in carrageenan induced paw edema model. The ethanolic extract has shown highly significant (p&lt;0.001) percentage of inhibition of paw edema, 57.43% and 60.56% at 5<sup>th</sup> hour at the low dose and high dose, respectively. Whereas analgesic activity was studied using tail immersion method in mice. The ethanolic root extract was shown highly significant (p&lt;0.001) analgesic activity with standard drug and high dose but, low dose showed less significant (p&lt;0.05) analgesic activity.&nbsp;Conclusions: The findings of the present study concluded that <em>A.cepa L</em> roots have potential to treat pain and inflammation and as a good source, novel natural analgesic and anti-inflammatory agents. The ethanolic extract of<em> A.</em>c<em>epa L</em> root showed highly significant analgesic and anti-inflammatory activity in mice and rats respectively.</p> 2020-02-27T00:00:00+0530 Copyright (c) DRUG DISCHARGE AND GAUGING OF ANTI EPILEPTIC DRUGS 2020-03-05T10:59:35+0530 Pradeep Kumar Reddy S Naga Subrahmanyam s Vineeth Kumar Padmini Alapati Anusha Gowd Narayan Swamy P <p>Background:Epilepsy is the second most common chronic neurological condition.&nbsp; Epilepsy means a tendency to have seizures i.e. recurrent unprovoked seizures. A seizure is a clinical events caused by an abnormal electrical discharge in brain (or) a transient disturbance of cerebral function due to an abnormal paroxysmal neuronal discharge in brain.Aims and Objectives: The main aim of the study is drug utilization evaluation of antiepileptic drugs among patients of different age groups in jayabharath hospital,Andhra Pradesh,. To assess drug utilization pattern of anti-epileptic drugs. METHODOLOGY:A prospective observational questionnaire based cross sectional study in 300 patients of various departments receiving atleastone AEDs. The subjects were included in the study only after they met the criteria for the study and after properly filling a informed consent form. The data was obtained by a questionnaire format and it is evaluated for utilization patterns, medication adherence. The cost of AEDs were calculated to evaluate total costs on each drug.RESULTS:Out of 300 patients, 210 were male and 90 were female. The age group 11- 20 years were found prominent with epilepsy. The average number of AEDs per patient was found to be 1.54. Among all the drugs prescribed phenytoin was the most common drug prescribed 223 (47.89%) for the treatment, followed by lorazepam 89 (19.09 %) and sodium valproate 40 (8.73 %). CONCLUSION:The use of AEDs was almost found to be rational. In this hospital the most commonly prescribed AEDs was phenytoin followed by lorazepam and in combinational therapy it was phenytoin + lorazepam. The utilization of drugs was obtained from the patients using questionnaire format and they showed high utilization of drugs.</p> 2020-02-27T00:00:00+0530 Copyright (c) 2020 EVALUATION OF DIURETIC AND SEDATIVE ACTIVITY FOR ETHANOLIC LEAVES EXTRACT OF BASELLA ALBA L. VAR RUBRA 2020-03-03T21:46:28+0530 Divya J Brahma Srinivasa Rao D Anil Kumar Y Ravi Kumar K <p>Herbal medicine is the oldest form of health care known to mankind. Medicinal plants can be important sources of unknown chemical substances with potential therapeutic effects. The study of plant species with diuretic effects is still a fruitful research in search of new diuretic and sedative drugs. The present study was carried out to evaluate the diuretic and sedative effect of ethanolic extract of <em>Basella alba (BAE) </em>in wistar rats &amp; mice by using Lipschitz model and Rota rod model respectively. The urine volume, electrolyte levels in rats and fall of time of mices from rota rod were measured. BAE showed significant (p&lt;0.05) diuretic and sedative activity of two doses (100mg/kg &amp; 200mg/kg, p.o) tested, When compared to control and drugs furosemide and diazepam respectively. Hence, the BAE possess diuretic and sedative activity.</p> 2020-02-27T00:00:00+0530 Copyright (c) 2020 Review on Drug Utilization Pattern in Outpatient General Department 2020-03-03T23:26:53+0530 Jaya Surya V Rama Brahma Reddy D Prasanthi G Sowmya L Naga Sai R <p>Drug utilization reviews DUR also referred to be as drug utilization evaluation DUE . It is defined as authorized, structured. Ongoing review of healthcare provider prescribing pharmacist dispensing and patient use of medication. Drug utilization reviews involve a detailed review of patient’s prescription and medication data before, during dispensing and after dispensing to ensure appropriate medication decisions making and positive patient outcomes. World health organization (WHO) defines drug utilization review as authorized research as the marketing, distribution, prescription and use of drug in a&nbsp; society, with a special emphasis on the resulting medical, social, and economic sequences. Inherent in the definition, such studies provide logical background for determining the rationality of drug use as well as providing the evidence&nbsp; based guidance for making the policies and making decisions at various levels of health care. This&nbsp; review studies are Aimed to discuss in detail on drug utilization pattern in out patient general department.</p> 2020-02-10T00:00:00+0530 Copyright (c) 2020 D. Rama Brahma Reddy PLANTS AND PHYTOCONSTITUENTS HAVING SUNSCREEN ACTIVITY 2020-03-03T23:39:53+0530 Prasanth B Amrutha Soman Johnson Jobin Parvathy S Narayanan Amala P John <p>Sunscreens are those preparation which are rubbed on to the skin surface for the purpose of protection from the harmful UV radiations from the sun. Exposure to those radiations can results in harmful effects such as cancer, edema, varied pigmentation and erythema as a result of DNA damage. Majority of organic chemicals used in sunscreen formulations have not been established as safe. Natural sunscreens gained importance over synthetic ones due to their less side effects, greater protection and easy availability. A wide range of natural products derived from plants, algae and propolis have shown potential photoprotective effect. Natural compounds including flavonoids, cinnamates,polyphenols,carotenoids,anthocyanins,triterpenoid saponins have shown desired Sun Protection Factor (SPF) in addition to anti-inflammatory and anti-oxidant property.</p> 2020-02-27T00:00:00+0530 Copyright (c) 2020 Prasanth B A Comprehensive Study on Nerivio Migra 2020-03-03T23:48:50+0530 Srinivas Pasula Thankachan Ledo Srionivasa Rao A Durga Prasad Beda <p>Migraine is&nbsp;one among&nbsp;the foremost&nbsp;prevalent and disabling disorders, characterized by recurrent headache attacks with nausea, vomiting, photophobia, and phonophobia. Nerivio Migra&nbsp;may be a&nbsp;breakthrough&nbsp;device&nbsp;for acute treatment of migraines. Attached to the patient's arm (below the shoulder),&nbsp;it's&nbsp;a clinically-tested wearable suited to be worn everywhere and at any time. Non steroidal anti inflammatory drugs (NSAIDs) and triptans, commonly used for acute migraine treatment<sup>3</sup>,&nbsp;may be ineffective, poorly tolerated, contraindicated, and if used in excess, may lead to medication overuse headache there is a great unmet need for alternative acute migraine treatments that are both effective and well tolerated. Non-invasive neuromodulation is safe, well tolerated, and may have fewer adverse effects than drugs. Remote electrical neuromodulation (REN)&nbsp;may be a&nbsp;novel acute migraine treatment that stimulates upper arm peripheral nerves to induce conditioned pain modulation (CPM)-an endogenous analgesia mechanism&nbsp;during which&nbsp;conditioning stimulation inhibits pain in remote body regions<strong>.</strong></p> 2020-02-27T00:00:00+0530 Copyright (c) CASE REPORT ON EPIDERMOLYSIS BULLOSA ACQUISITA 2020-03-03T23:35:42+0530 SHAIK FIROZ Venkat Naga Priyanka kolakaluri HEMARAVALI KAMISETTY <p>Epidermolysis bullosa acquisita (EBA) is rare autoimmune blistering of the skin disease but not inherited and characterized by autoantibodies to collagen VII. It is a rare with an incidence rate of 0.26 / million population. Treatment include oral corticosteroids (E.g.: pre-dnisone), anti-inflammatory agents, and immunosuppressants&nbsp; (e.g.: azathioprine).&nbsp; Patients who are on long-term oral steroid treatment may be advised to take calcium and bisphosphonates to reduce the risk of osteoporosis that can be associated with steroid use. A case of 13 years old boy initially presented with bullous vesicular lesions all over the body. 5 months history of progressive trauma persuaded papules and vesicles on his hands, and face.</p> 2020-02-29T00:00:00+0530 Copyright (c) 2020 SHAIK FIROZ, Venkata Naga Priyanka kolakaluri, HEMARAVALI KAMISETTY