FORMULATION AND EVALUATION OF PHYSOSTIGMINE-TRANSDERMAL PATCH
In present study transdermal drug delivery of Physostigmine was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route. Matrix type of transdermal patches was developed by using polymers Eudragit-L100, HPMCk4M and HPMCk15M.Transdermal patches were prepared by employing solvent casting method. Propylene glycol and Tween80 were selected as permeation enhancer and plasticizer. Among all the formulations P6 formulation was found to be best and shown 96.5% drug release in 12 hours. For P6 formulation release kinetics were applied and it was observed that the formulation was following peppas mechanism of drug release.
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