FORMULATION AND EVALUATION OF PHYSOSTIGMINE-TRANSDERMAL PATCH
Abstract
In present study transdermal drug delivery of Physostigmine was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route. Matrix type of transdermal patches was developed by using polymers Eudragit-L100, HPMCk4M and HPMCk15M.Transdermal patches were prepared by employing solvent casting method. Propylene glycol and Tween80 were selected as permeation enhancer and plasticizer. Among all the formulations P6 formulation was found to be best and shown 96.5% drug release in 12 hours. For P6 formulation release kinetics were applied and it was observed that the formulation was following peppas mechanism of drug release.
Downloads
References
2. Rakesh Pahwa, Lovely Chhabra , Avneet Kaur Lamba , Sumit Jindal and Arvind Rathour Formulation and in-vitro evaluation of effervescent floating tablets of an antiulcer agent Journal of Chemical and Pharmaceutical Research, 2012, 4(2):1066-1073
3. Md. Haider Ali1 , Mohiuddin Ahmed Bhuiyan2 , Md. Selim Reza3 and Samira Karim1 Formulation and In vitro Evaluation of Oral Floating Tablets of Salbutamol Sulphate: Comparison with Effervescent Tablets Dhaka Univ. J. Pharm. Sci. 15(2): 203-208, 2016 (December)\
4. C Haranath, J Raveendra Reddy, N Devanna. Formulation and In-Vitro Evaluation of Effervescent Floating Tablets of an Antibacterial Drug. Inventi Impact: Pharm Tech, 2016(4):145-151, 2016.
5. AkhlakAhmed, Narendra Kr. Goyal and Pramod K. Sharma Effervescent Floating Drug Delivery System: A Review Global Journal of Pharmacology 8 (4): 478-485, 2014
6. Ali Raza , Nadeem Irfan Bukhari, Sabiha Karim y , Muhammad Ahsan Hafiz, Uzma Hayat Floating tablets of minocycline hydrochloride: Formulation, in-vitro evaluation and optimization Future Journal of Pharmaceutical Sciences 3 (2017) 131e139
7. K.Chaitanya, Sellappan Velmurugan Formulation And Evaluation Of Levodopa Effervescent Floating Tablets Int J Pharm Pharm Sci, Vol 7, Issue 5,189-193
8. Komuravelly Someshwar Kalyani Chithaluru, Tadikonda Ramarao K. K. Kalyan Kumar Formulation and evaluation of effervescent floating tablets of tizanidine hydrochloride Acta Pharm. 61 (2011) 217–226
9. Harsharan Pal Singh, Ashmeet Kaur , Ishpreet Kaur Formulation and evaluation of effervescent floating tablet of famotidine with natural polymer chitosan Asian Pac. J. Health Sci., 2014; 1(4): 517-523
10. Ali Kadivar , Behnam Kamalidehghan , Hamid Akbari Javar , Ehsan Taghizadeh Davoudi , Nurul Dhania Zaharuddin , Bahareh Sabeti , Lip Yong Chung , Mohamed Ibrahim Noordin Formulation and In Vitro, In Vivo Evaluation of Effervescent Floating Sustained-Release Imatinib Mesylate Tablet PLOS ONE | DOI:10.1371/journal.pone.0126874 June 2, 2015.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright © Author(s) retain the copyright of this article.
