A Comprehensive Study on Nerivio Migra
Abstract
Migraine is one among the foremost prevalent and disabling disorders, characterized by recurrent headache attacks with nausea, vomiting, photophobia, and phonophobia. Nerivio Migra may be a breakthrough device for acute treatment of migraines. Attached to the patient's arm (below the shoulder), it's a clinically-tested wearable suited to be worn everywhere and at any time. Non steroidal anti inflammatory drugs (NSAIDs) and triptans, commonly used for acute migraine treatment3, may be ineffective, poorly tolerated, contraindicated, and if used in excess, may lead to medication overuse headache there is a great unmet need for alternative acute migraine treatments that are both effective and well tolerated. Non-invasive neuromodulation is safe, well tolerated, and may have fewer adverse effects than drugs. Remote electrical neuromodulation (REN) may be a novel acute migraine treatment that stimulates upper arm peripheral nerves to induce conditioned pain modulation (CPM)-an endogenous analgesia mechanism during which conditioning stimulation inhibits pain in remote body regions.
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References
2. Society (IHS) HCC of the IH. The international classification of headache disorders, (beta version). Cephalalgia. 2013; 33: 629- 808
3. Silva AND, Tepper SJ. Acute treatment of migraines. CNS Drugs. 2012; 26: 823- 839.
4. Goadsby PJ, Sprenger T. Current practice and future directions in the prevention and acute management of migraine. Lancet Neurol. 2010; 9: 285- 298.
5. Diener H-C, Limmroth V. Medication-overuse headache: A worldwide problem. Lancet Neurol.2004; 3: 475- 483.
6. Bigal ME, Lipton RB. Overuse of acute migraine medications and migraine chronification. Curr Pain Headache Rep. 2009; 13: 301- 307.
7. Katić BJ, Krause SJ, Tepper SJ, Hu HX, Bigal ME. Adherence to acute migraine medication: What does it mean, why does it matter? Headache. 2010; 50: 117- 129.
8. Bigal M, Krymchantowski AV, Lipton RB. Barriers to satisfactory migraine outcomes. What have we learned, where do we stand? Headache. 2009; 49: 1028- 1041.
9. Alam A, Munjal S, Reed M, et al. Triptan use and discontinuation in a representative sample of persons with migraine: Results from migraine in America symptoms and treatment (MAST) study (P4.10-019). Neurology. 2019; 92(Suppl. 15) P4.10-019.
10. Puledda F, Goadsby PJ. An update on non-pharmacological neuromodulation for the acute and preventive treatment of migraine. Headache. 2017; 57: 685- 691.
11. Starling A. Noninvasive neuromodulation in migraine and cluster headache. CurrOpin Neurol.2018; 31: 268- 273.
12. Nir R-R, Yarnitsky D. Conditioned pain modulation. CurrOpin Support Palliat Care. 2015; 9: 131- 137.
13. Yarnitsky D, Volokh L, Ironi A, et al. Nonpainful remote electrical stimulation alleviates episodic migraine pain. Neurology. 2017; 88: 1250- 1255.