A Review on Herbal Drug Therapy for Diabetes Mellitus
Abstract
This review focuses on the study of herbal drugs used in Diabetes mellitus treatment. Diabetes mellitus becomes a common metabolic disorder that poses a serious threat to the world's public health. Approximately 60 percent of the world's population use traditional medicines derived from medicinal plants. Due to lower side effects and low cost, herbal formulations are favored. Synonymous with herbal medicine, phytomedicine or botanical medicine, plants are used for medicinal purposes. Herbal selection may depend on a number of factors, including the stage of diabetes progression, the types of comorbidities that patients have, availability, affordability, and herbal safety profile. A list is compiled of medicinal plants with proven antidiabetic and related beneficial effects and herbal medicines used in diabetes treatment.
Keywords:
Diabetes mellitus, herbal drugs, treatment, Insulin secretion, antidiabetic
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References
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7. J. L. Leahy, I. B. Hirsch, K. A. Peterson, and D. Schneider, “Targeting β-cell function early in the course of therapy for type 2 diabetes mellitus,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 9, pp. 4206–4216, 2010. View at Publisher • View at Google Scholar • View at Scopus
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9. R. A. Defronzo, “From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus,” Diabetes, vol. 58, no. 4, pp. 773–795, 2009. View at Publisher • View at Google Scholar • View at Scopus
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11. A. Tahrani, C. J. Bailey, S. Del Prato, and A. H. Barnett, “Management of type 2 diabetes: new and future developments in treatment,” The Lancet, vol. 378, no. 9786, pp. 182–197, 2011. View at Publisher • View at Google Scholar • View at Scopus
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16. J. Hlebowicz, A. Hlebowicz, S. Lindstedt et al., “Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects,” American Journal of Clinical Nutrition, vol. 89, no. 3, pp. 815–821, 2009. View at Publisher • View at Google Scholar • View at Scopus
17. Grover J.K., Yadav S., Vats V. Medicinal plants of India with antidiabetic potential. J. Ethnopharmacol. 2002;81:81–100. [PubMed] [Google Scholar]
18. 2. Scartezzini P., Sproni E. Review on some plants of Indian traditional medicine with antioxidant activity. J. Ethnopharmacol. 2000;71:23–43. [PubMed] [Google Scholar]
19. 3. Seth S.D., Sharma B. Medicinal plants of India. Indian J. Med. Res. 2004;120:9–11. [PubMed] [Google Scholar]
20. 4. Ramachandran A., Snehalatha C., Viswanathan V. Burden of type 2 diabetes and its complications- the Indian scenario. Curr. Sci. 2002;83:1471–1476. [Google Scholar]
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23. 7. Baynes J.W., Thorpe S.R. The role of oxidative stress in diabetic complications. Curr. Opin. Endocrinol. 1997;3:277–284. [Google Scholar]
24. Mestry S.N., Dhodi J.B., Kumbhar S.B., Juvekar A.R. Attenuation of diabetic nephropathy in streptozotocin-induced diabetic rats by Punica granatum Linn. leaves extract. J Tradit Complement Med. 2017;7(3):273–280. [PMC free article] [PubMed] [Google Scholar]
25. 73. Cui L., Liu M., Chang X.Y., Sun K. The inhibiting effect of the Coptis chinensis polysaccharide on the type II diabetic mice. Biomed Pharmacother. 2016;81:111–119. [PubMed] [Google Scholar]
26. 74. Tiong S.H., Looi C.Y., Arya A. Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae) Fitoterapia. 2015;102:182–188. [PubMed] [Google Scholar]
27. 75. Singh S.N., Vats P., Suri S. Effect of an antidiabetic extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats. J Ethnopharmacol. 2001;76(3):269–277. [PubMed] [Google Scholar]
28. 76. Gul M.Z., Attuluri V., Qureshi I.A., Ghazi I.A. Antioxidant and α-glucosidase inhibitory activities of Murraya koenigii leaf extracts. Pharmacogn J. 2012;4(32):65–72. [Google Scholar]
29. 77. Tembhurne S.V., Sakarkar D.M. Anti-obesity and hypoglycemic effect of ethanolic extract of Murraya koenigii (L) leaves in high fatty diet rats. Asian Pac J Trop Dis. 2012;2(suppl 1):S166–S168. [Google Scholar]
30. 78. Mousavi L., Salleh R.M., Murugaiyah V., Asmawi M.Z. Hypoglycemic and anti-hyperglycemic study of Ocimum tenuiflorum L. leaves extract in normal and streptozotocin-induced diabetic rats. Asian Pac J Trop Biomed. 2016;6(12):1029–1036. [Google Scholar]
31. 79. Irondi E.A., Oboh G., Akindahunsi A.A., Boligon A.A., Athayde M.L. Phenolic composition and inhibitory activity of Mangifera indica and Mucuna urens seeds extracts against key enzymes linked to the pathology and complications of type 2 diabetes. Asian Pac J Trop Biomed. 2014;4(11):903–910. [Google Scholar]
32. 16. Wadood A., Wadood N., Shah S.A. Effects of Acacia arabica and Caralluma edulis on blood glucose levels on normal and alloxan diabetic rabbits. J. Pakistan Med. Assoc. 1989;39:208–212. [PubMed] [Google Scholar]
33. 17. Karunanayake E.H., Welihinda J., Sirimanne S.R., Sinnadorai G. Oral hypoglycemic activity of some medicinal plants of Sri Lanka. J. Ethnopharmacol. 1984;11:223–231. [PubMed] [Google Scholar]
34. 18. Roman-Ramos R., Flores-Saenz J.L., Alaricon-Aguilar F.J. Antihyperglycemic effect of some edible plants. J. Ethnopharmacol. 1995;48:25–32. [PubMed] [Google Scholar]
35. 19. Kumari K., Mathew B.C., Augusti K.T. Antidiabetic and hypolipidaemic effects of S-methyl cysteine sulfoxide, isolated from Allium cepa Linn. Ind. J. Biochem. Biophys. 1995;32:49–54. [PubMed] [Google Scholar]
36. 20. Mathew P.T., Augusti K.T. Hypoglycemic effects of onion, Allium cepa Linn. on diabetes mellitus- a preliminary report. Ind. J. Physiol. Pharmacol. 1975;19:213–217. [PubMed] [Google Scholar]
37. 21. Sheela C.G., Augusti K.T. Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn. Indian J. Exp. Biol. 1992;30:523–526. [PubMed] [Google Scholar]
38. 22. Bever B.O., Zahnd G.R. Plants with oral hypoglycemic action. Quart. J. Crude Drug Res. 1979;17:139–146. [Google Scholar]
2. J. P. Boyle, M. M. Engelgau, T. J. Thompson et al., “Estimating prevalence of type 1 and type 2 diabetes in a population of African Americans with diabetes mellitus,” American Journal of Epidemiology, vol. 149, no. 1, pp. 55–63, 1999. View at Google Scholar • View at Scopus
3. S. Attele, Y. P. Zhou, J. T. Xie et al., “Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component,” Diabetes, vol. 51, no. 6, pp. 1851–1858, 2002. View at Google Scholar • View at Scopus
4. Cashen, S. Lopez, F. Gao et al., “A phase II Study of plerixafor (AMD3100) plus G-CSF for autologous hematopoietic progenitor cell mobilization in patients with hodgkin lymphoma,” Biology of Blood and Marrow Transplantation, vol. 14, no. 11, pp. 1253–1261, 2008. View at Publisher • View at Google Scholar • View at Scopus
5. M. Laakso, “Insulin resistance and its impact on the approach to therapy of Type 2 diabetes,” International Journal of Clinical Practice, Supplement, no. 121, pp. 8–12, 2001. View at Google Scholar • View at Scopus
6. R. S. Clements and D. S. H. Bell, “Complications of diabetes: prevalence, detection, current treatment, and prognosis,” American Journal of Medicine, vol. 79, no. 5, pp. 2–7, 1985. View at Google Scholar • View at Scopus
7. J. L. Leahy, I. B. Hirsch, K. A. Peterson, and D. Schneider, “Targeting β-cell function early in the course of therapy for type 2 diabetes mellitus,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 9, pp. 4206–4216, 2010. View at Publisher • View at Google Scholar • View at Scopus
8. R. Gianani, “Beta cell regeneration in human pancreas,” Seminars in Immunopathology, vol. 33, no. 1, pp. 23–27, 2011. View at Google Scholar
9. R. A. Defronzo, “From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus,” Diabetes, vol. 58, no. 4, pp. 773–795, 2009. View at Publisher • View at Google Scholar • View at Scopus
10. M. Szabat, F. C. Lynn, B. G. Hoffman et al., “Maintenance of beta-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology,” Diabetes, vol. 61, no. 6, pp. 1365–1371, 2012. View at Google Scholar
11. A. Tahrani, C. J. Bailey, S. Del Prato, and A. H. Barnett, “Management of type 2 diabetes: new and future developments in treatment,” The Lancet, vol. 378, no. 9786, pp. 182–197, 2011. View at Publisher • View at Google Scholar • View at Scopus
12. J. F. Tanti and J. Jager, “Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation,” Current Opinion in Pharmacology, vol. 9, no. 6, pp. 753–762, 2009. View at Publisher • View at Google Scholar • View at Scopus
13. D. Jones, “Diabetes field cautiously upbeat despite possible setback for leading SGLT2 inhibitor,” Nature Reviews Drug Discovery, vol. 10, no. 9, pp. 645–646, 2011. View at Google Scholar
14. G. Encina, F. Ezquer, P. Conget, and Y. Israel, “Insulin is secreted upon glucose stimulation by both gastrointestinal enteroendocrine K-cells and L-cells engineered with the preproinsulin gene,” Biological Research, vol. 44, no. 3, pp. 301–305, 2011. View at Google Scholar
15. R. E. Pratley and M. Gilbert, “Targeting incretins in type 2 diabetes: role of GLP-1 receptor agonists and DPP-4 inhibitors,” Review of Diabetic Studies, vol. 5, no. 2, pp. 73–94, 2008. View at Publisher • View at Google Scholar • View at Scopus
16. J. Hlebowicz, A. Hlebowicz, S. Lindstedt et al., “Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects,” American Journal of Clinical Nutrition, vol. 89, no. 3, pp. 815–821, 2009. View at Publisher • View at Google Scholar • View at Scopus
17. Grover J.K., Yadav S., Vats V. Medicinal plants of India with antidiabetic potential. J. Ethnopharmacol. 2002;81:81–100. [PubMed] [Google Scholar]
18. 2. Scartezzini P., Sproni E. Review on some plants of Indian traditional medicine with antioxidant activity. J. Ethnopharmacol. 2000;71:23–43. [PubMed] [Google Scholar]
19. 3. Seth S.D., Sharma B. Medicinal plants of India. Indian J. Med. Res. 2004;120:9–11. [PubMed] [Google Scholar]
20. 4. Ramachandran A., Snehalatha C., Viswanathan V. Burden of type 2 diabetes and its complications- the Indian scenario. Curr. Sci. 2002;83:1471–1476. [Google Scholar]
21. 5. Matteucci E., Giampietro O. Oxidative stress in families of type 1 diabetic patients. Diabetes Care. 2000;23:1182–1186. [PubMed] [Google Scholar]
22. 6. Oberlay L.W. Free radicals and diabetes. Free Radic. Biol. Med. 1988;5:113–124. [PubMed] [Google Scholar]
23. 7. Baynes J.W., Thorpe S.R. The role of oxidative stress in diabetic complications. Curr. Opin. Endocrinol. 1997;3:277–284. [Google Scholar]
24. Mestry S.N., Dhodi J.B., Kumbhar S.B., Juvekar A.R. Attenuation of diabetic nephropathy in streptozotocin-induced diabetic rats by Punica granatum Linn. leaves extract. J Tradit Complement Med. 2017;7(3):273–280. [PMC free article] [PubMed] [Google Scholar]
25. 73. Cui L., Liu M., Chang X.Y., Sun K. The inhibiting effect of the Coptis chinensis polysaccharide on the type II diabetic mice. Biomed Pharmacother. 2016;81:111–119. [PubMed] [Google Scholar]
26. 74. Tiong S.H., Looi C.Y., Arya A. Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae) Fitoterapia. 2015;102:182–188. [PubMed] [Google Scholar]
27. 75. Singh S.N., Vats P., Suri S. Effect of an antidiabetic extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats. J Ethnopharmacol. 2001;76(3):269–277. [PubMed] [Google Scholar]
28. 76. Gul M.Z., Attuluri V., Qureshi I.A., Ghazi I.A. Antioxidant and α-glucosidase inhibitory activities of Murraya koenigii leaf extracts. Pharmacogn J. 2012;4(32):65–72. [Google Scholar]
29. 77. Tembhurne S.V., Sakarkar D.M. Anti-obesity and hypoglycemic effect of ethanolic extract of Murraya koenigii (L) leaves in high fatty diet rats. Asian Pac J Trop Dis. 2012;2(suppl 1):S166–S168. [Google Scholar]
30. 78. Mousavi L., Salleh R.M., Murugaiyah V., Asmawi M.Z. Hypoglycemic and anti-hyperglycemic study of Ocimum tenuiflorum L. leaves extract in normal and streptozotocin-induced diabetic rats. Asian Pac J Trop Biomed. 2016;6(12):1029–1036. [Google Scholar]
31. 79. Irondi E.A., Oboh G., Akindahunsi A.A., Boligon A.A., Athayde M.L. Phenolic composition and inhibitory activity of Mangifera indica and Mucuna urens seeds extracts against key enzymes linked to the pathology and complications of type 2 diabetes. Asian Pac J Trop Biomed. 2014;4(11):903–910. [Google Scholar]
32. 16. Wadood A., Wadood N., Shah S.A. Effects of Acacia arabica and Caralluma edulis on blood glucose levels on normal and alloxan diabetic rabbits. J. Pakistan Med. Assoc. 1989;39:208–212. [PubMed] [Google Scholar]
33. 17. Karunanayake E.H., Welihinda J., Sirimanne S.R., Sinnadorai G. Oral hypoglycemic activity of some medicinal plants of Sri Lanka. J. Ethnopharmacol. 1984;11:223–231. [PubMed] [Google Scholar]
34. 18. Roman-Ramos R., Flores-Saenz J.L., Alaricon-Aguilar F.J. Antihyperglycemic effect of some edible plants. J. Ethnopharmacol. 1995;48:25–32. [PubMed] [Google Scholar]
35. 19. Kumari K., Mathew B.C., Augusti K.T. Antidiabetic and hypolipidaemic effects of S-methyl cysteine sulfoxide, isolated from Allium cepa Linn. Ind. J. Biochem. Biophys. 1995;32:49–54. [PubMed] [Google Scholar]
36. 20. Mathew P.T., Augusti K.T. Hypoglycemic effects of onion, Allium cepa Linn. on diabetes mellitus- a preliminary report. Ind. J. Physiol. Pharmacol. 1975;19:213–217. [PubMed] [Google Scholar]
37. 21. Sheela C.G., Augusti K.T. Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn. Indian J. Exp. Biol. 1992;30:523–526. [PubMed] [Google Scholar]
38. 22. Bever B.O., Zahnd G.R. Plants with oral hypoglycemic action. Quart. J. Crude Drug Res. 1979;17:139–146. [Google Scholar]
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31-12-2019
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Dandu G, Basu VR, P C, D R, Suresh babu S babu, R AB. A Review on Herbal Drug Therapy for Diabetes Mellitus. World Journal of Current Med and Pharm Research [Internet]. 2019Dec.31 [cited 2024Dec.6];1(6):203-8. Available from: https://wjcmpr.com/index.php/journal/article/view/62
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