A Prospective Observational Study to Evaluate Safety and Efficacy of Intraarticular Administration of Triamcinolone Acetonidein Knee Osteoarthritis in A Tertiary Care Hospital
Abstract
Objective: Osteoarthritis is a chronic disease marked by cartilage deterioration, affecting millions globally. Although incurable, it can be managed with adjuvant therapy. This study aims to assess the safety and efficacy of intra-articular Triamcinolone acetonide in knee OA, a corticosteroid used for OA, Rheumatoid arthritis, gouty arthritis, and skin disorders.
Methods: In a prospective observational study with 120 participants, pain severity was evaluated using numerical pain rating and KL-grade scales, while joint space narrowing was assessed via X-ray reports. Subjects were categorized by severity and prescribed intra-articular Triamcinolone acetonide, analgesics, NSAIDs, PPIs, and supplements. They were monitored for pain reduction.
Results: Pain scores were evaluated using NPRS and KL-grade scale: initially, severe pain affected 4.1% (n=5), moderate 86.6% (n=104), mild 9.1% (n=11). After three follow-ups over 6 months, severe pain decreased to 1.6% (n=2), moderate to 84.1% (n=101), and mild increased to 14.1% (n=17).
Conclusion: Our study concludes that intra-articular triamcinolone acetonide, combined with oral and topical analgesics, PPIs, nutritional, and vitamin supplements, is safer and more effective for knee OA, improving patient quality of life, reducing disease severity, prescription charges, and adverse drug reactions.
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References
2. National Institute of Arthritis and Musculoskeletal and Skin Diseases. Diagnosis, Treatment, and Steps to Take. Available from: https://www.niams.nih.gov/health-topics/osteoarthritis/diagnosis-treatment-and-steps-to-take.
3. WebMD Editorial Contributors Reviewer: David Zelman, MD Insights into Osteoarthritis Causes from WebMDNovember 02, 2022https://www.webmd.com/osteoarthritis/osteoarthritis-causes
4. Berryman LY. Pharmacotherapy Handbook. 2nd Edition. The Annals of Pharmacotherapy [Internet]. 2000 Dec;34(12):1490–0. Available from: http://fac.ksu.edu.sa/sites/default/files/Pharmacotherapy_Handbook_7th_Edition.pdf
5. Williams C, Ampat G. Glucosamine Sulfate [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2020. Available from: https://www.ncbi.nlm.nih.gov/books/NBK558930/
6. Gursharan Sidhu, Preuss CV. Triamcinolone [Internet]. Nih.gov. StatPearls Publishing; 2019. Available from: https://www.ncbi.nlm.nih.gov/books/NBK544309/
7. Highlights of Prescribing Information [Internet]. [cited 2024 Mar 13]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/211950s000lbl.pdf
8. KENALOG ® -10 INJECTION (triamcinolone acetonide injectable suspension, USP) [Internet]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/012041s045lbl.pdf
9. Hayes B, Kittelson A, Loyd B, Wellsandt E, Flug J, Stevens-Lapsley J. Assessing radiographic knee osteoarthritis: an online training tutorial for the Kellgren-Lawrence Grading Scale. MedEdPORTAL. 2016 Nov 18; 12:10503. https://doi.org/10.15766/mep_2374-8265.10503
10. N Y. Diacerein- A gold standard analgesic in management of osteoarthritis. Indian Journal of Clinical Anaesthesia [Internet]. 2020 May 15 [cited 2024 Mar 13];7(1):3–7.
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