Heavy metal analysis, pesticide residue analysis and aflatoxin assay of siddha herbal formulationmadhumega nivarani chooranam
Abstract
Aim
The aim of the study was to assess the Heavy metal analysis, pesticide residue and aflatoxin assay of Siddha herbal formulation “Madhumega Nivarani Chooranam”, used for the management of Madhumegam (Type-II Diabetes mellitus)
Materials and Method
According to the procedure that is stated in the Siddha text "The Pharmacopoeia of Siddha Research Medicines," the siddha poly herbal formulation was formulated in accordance with good manufacturing practises (GMP) regulations. Aflatoxin assay, pesticide residue analysis, and heavy metal analysis these studies were all carried out at Nobel Research Solutions in Chennai.
Results
The above assay, which used AAS to identify Heavy metals in the siddha medicine Madhumega Nivaran iChooranam revealed BDL (below detective level), presence of lead and arsenic at 1.14 PPM and 0.34 PPM level as listed in the table. The study revealed absence of Aflatoxin and pesticide residues in the given sample. It is indicating that this drug is safe to use.
Conclusion
According to the results, the sample Madhumega Nivarani Chooranam (MNC) has been determined to be safe throughout the present screening process, with the presence of heavy metals below the detection limit, Devoid of aflatoxins, as well as Residues of Pesticides. Hence, the current study reveals the drug was safe for therapeutic use
Downloads
References
2.A. Anu, U. Chitra, N. Anbu. Standardisation of MurungaiNei: A Siddha Formulation. Int. J. Res. Ayurveda Pharm. 2023;14(4):58- 62
3. Juliet L, Standardization of Poly Herbal Siddha Medicine EladhiChooranam International Journal of Pharmaceutical Science Invention ISSN (Online): 2319 – 6718, ISSN (Print): 2319 – 670X www.ijpsi.org || Volume 4 Issue 6 || June 2015 || PP. 33-37
4. Dr.M.Shanmugavel .L.I.M.H.P.I.M ,Dr.G.D.Naidu I.L.W.A The Pharmacopoeia of siddha Research Medicine Chapter 1,Pg.No:106-107
5. Nille GC, Mishra SK, Chaudhary AK, Reddy KRC. Ethnopharmacological, Phytochemical, Pharmacological, and Toxicological Review on Senna auriculata (L.) Roxb.: A Special Insight to Antidiabetic Property. Front Pharmacol. 2021 Aug 24;12:647887. doi: 10.3389/fphar.2021.647887. PMID: 34504420; PMCID: PMC8423098.
6. Arunachalam K, Yang X, San TT. Tinosporacordifolia (Willd.) Miers: Protection mechanisms and strategies against oxidative stress-related diseases. J Ethnopharmacol. 2022 Jan 30;283:114540. doi: 10.1016/j.jep.2021.114540. Epub 2021 Sep 9. PMID: 34509604.
7. Rashid F, Javaid A, Mahmood-Ur-Rahman, Ashfaq UA, Sufyan M, Alshammari A, Alharbi M, Nisar MA, Khurshid M. Integrating Pharmacological and Computational Approaches for the Phytochemical Analysis of Syzygium cumini and Its Anti-Diabetic Potential. Molecules. 2022 Sep 5;27(17):5734. doi: 10.3390/molecules27175734. PMID: 36080496; PMCID: PMC9458221.
8. Sapkota BK, Khadayat K, Sharma K, Raut BK, Aryal D, Thapa BB, Parajuli N. Phytochemical Analysis and Antioxidant and Antidiabetic Activities of Extracts from Bergeniaciliata, Mimosa pudica, and Phyllanthusemblica. AdvPharmacol Pharm Sci. 2022 Jul 7;2022:4929824. doi: 10.1155/2022/4929824. PMID: 35845257; PMCID: PMC9283070.
9. Amiza, Ghazala Yaseen, SammiaShahid. Comprehensive Review on Phytopharmacological Potential of Gymnemasylvestre. Asian J. Pharm. Tech. 2020; 10(3):217-220. doi: 10.5958/2231-5713.2020.00036.7
10. Raju MG and Reddy THS: Anti-diabetic and hypolipidemic activity of methanolic extract of aristolochiabracteolata on streptozotocin induced diabetic rat model. Int J Pharm Sci Res 2017; 8(3): 1173-77.doi: 10.13040/IJPSR.0975-8232.8(3).1173-77
11. Pillai C.Kannusamy. SikitchaRathnaDeepamEnnumVaidhiyaNool. Chennai: B. RathnaNayakkar& Sons;2018.
12.Suresh Balaji N, Physicochemical and phytochemical analysis of siddha polyherbal formulation MadhumegaNivarani Chooranam, World Journal of Current Medical and Pharmaceutical Research 2023; Volume 5(5) Page no : 198-201

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.