Daruharidra (Berberisaristata Dc.) An Important Ayurvedic Medicinal Plant - A Review
Abstract
Herbal medicinal plants play an important role in the traditional system of medicine, they have been used since centuries in various health systems like Ayurveda, Siddha and Unani etc. Daruharidra botanically identifies asBerberis aristata is well known medicinal plant in Ayurveda which is used alone or in combination with other medicinal plants. This medicinal plant is very useful in skin diseases like skin inflammation and psoriasis and apart from this it is also used in various diseases like jaundice, splenomegaly, rheumatoid arthritis, fever, morning sickness etc. A major bioactive marker of this plant is berberine, which is known for its activity against cholera, acute diarrhea, amoebiasis and latent malaria and for the treatment of oriental lesions caused by Leishmaniatropica. Although Berberis aristata is officially considered as Dahruharidra, review revealed that B. asiatica, and other species of Berberis like chytria are also taken under the name of Daruharidra. All the information about Daruharidra has been discussed in this review.
Keywords:
Daruharidra, Berberis aristata, berberine, skin disease
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References
1. Patel Pineshkumar S, Gajera V, Lambole V, Shah DP. (2019). PHYTOCHEMISTRY AND PHARMACOLOGICAL ACTIVITIES OF BERBERIS ARISTATA: AN OVERVIEW
2. N.Srikanth, The Actions and uses of Indigenous Ophthalmic Drugs, Chokhambha Sanskrit Prathisthan, Delhi, 2000.
3. J.P.N. Chanssuria, Studies on wound healing and effect of indigenous drugs on it., 1975; 198.
4. Dhar, M.L. et al, Screening of plants for biological activity part-1, Indian J. Exptl. Biol., 1968; 6: 232.
5. Shinwari, Z. K. (2010). Medicinal plants research in Pakistan. Journal of medicinal plants research, 4(3), 161- 176.
6. Muralidhar, C. V., &Kiran, K. K. (2018) A COMPREHENSIVE REVIEW OF DARUHARIDRA (BerberisAristata).
7. Komal, S., Ranjan, B., Neelam, C., Birendra, S., & Kumar, S. N. (2011). Berberisaristata: A review. Int J Res Ayurveda Pharm, 2(2), 383-388.
8. Chaudhari, V. M., & Kokate, K. K. A COMPREHENSIVE REVIEW OF DARUHARIDRA. International Journal of Research in Ayurveda and Medical Sciences, 1, 153-159.
9. Dravyaguna Hastamlaka by Vaidya Banwari Lal Misra edited by Vaidya Santosh Kumar Sharma Khandal published by Publication Scheme revised 5th edition, 437.
10. Khory, R. N., &Katrak, N. N. (1903). MateriaMedica of India and their therapeutics. Caxton Works.
11. Berberis [home page on internet] [cited on 2010 Sep 15] available on http://en.wikipedia.org/wiki/Berberis
12. Parmar, C., &Kaushal, M. K. (1982). Berberisaristata: Wild fruits. Kalyani Publishing Ludhiana, 10-14.
13. Kala, C. P., Dhyani, P. P., &Sajwan, B. S. (2006). Developing the medicinal plants sector in northern India: challenges and opportunities. Journal of Ethnobiology and Ethnomedicine, 2(1), 1-15.
14. Malairajan, P., Gopalakrishnan, G., Narasimhan, S., &Veni, K. J. K. (2006). Analgesic activity of some Indian medicinal plants. Journal of ethnopharmacology, 106(3), 425-428.
15. Parmar C and Kaushal MK. Berberisaristata: Indian: Wild Fruits. Kalyani Publishers, New Delhi, India. 1982; 10–14.
16. Rashmi, Rajasekaran A, Pant Jagdish. The genus berberis Linn: a review. Pharmacognosy review 2008 Jul-dec; 2(4):368-385.
17. Chakravarti, K. K., Dhar, D. C., & Siddiqui, S. (1950). Alkaloidalconsistuents of the bark ofBerberisaristata. Journal of Scientific and Industrial Research, (7), 161-4
18. Blasko, G., Murugesan, N., Freyer, A. J., Shamma, M., & Ansari, A. A. (1982). Karachine: an unusual protoberberine alkaloid. Journal of the American Chemical Society, 104(7), 2039-2041.
19. RAHMAN, A., & Ansari, A. A. (2011). Alkaloids of Berberisaristata-isolation of aromoline and oxyberberine. Journal of The Chemical Society of Pakistan, 5(4), 283.
20. Saied, S., &Batool, S. (2007). ShaistaNaz, Phytochemical studies of Berberisaristata, J. Basic Appl. Sci, 3(1), 1-3.
21. Blasko, G., ANSARI, A. A., & RAHMAN, A. U. (1982). Taxilamine, a pseudobenzylisoquinoline alkaloid.
22. Sivakumar, R., & KAMACHANDRAN NAIR, A. G. (1991). Polyphenolic constituents of the flowers of Berberisaristata. Journal of the Indian Chemical Society, 68(9), 531-532.
23. Sivakumar, R., & KAMACHANDRAN NAIR, A. G. (1991). Polyphenolic constituents of the flowers of Berberisaristata. Journal of the Indian Chemical Society, 68(9), 531-532.
24. Katiyar, D., Singh, R. K., Singh, S., Singh, D., & Singh, V. (2011). Isolation and characterization of ndocosane from heartwood of Berberisaristata. International Journal of Pharmaceutical Sciences and Research, 2(2), 331.
25. Kasture, V. S., &Gharate, M. K. (2011). SIMPLE AND RAPID SCHEME OF STANDARDIZATION OF LOHASAVA. international Journal of Ayurvedic and Herbal Medicine, 1(03)
26. Sharma PV. Darvayaguna Vigyan Vol-II, Published by Choukhambha Bharti academy, Varanasi, Reprint 1998 pg. 539
27. Pandey, G. (2004). Dravyagunavijnana. Part III, ChowkhambaKrishnadas Academy, Varanasi (Reprint), 852.
28. J.P.N. Chanssuria, Studies on wound healing and effect of indigenous drugs on it., 1975; 198.
29. WebMD.Tree-turmeric: Uses, Side effects, Doses, Interactions [Internet].Atlanta [last updated in 2016].
30. Sohni, Y. R., & Bhatt, R. M. (1996). Activity of a crude extract formulation in experimental hepatic amoebiasis and in immunomodulation studies. Journal of ethnopharmacology, 54(2-3), 119-124.
31. Gilani, A. U., &Janbaz, K. H. (1995). Studies on protective effect of Cyperusscariosus extract on acetaminophen and CCl4-inducedhepatotoxicity. General pharmacology, 26(3), 627-631.
32. Tsai, P. L., & Tsai, T. H. (2004). Hepatobiliary excretion of berberine. Drug Metabolism and Disposition, 32(4), 405-412.
33. Feng, Y., Cheung, K. F., Wang, N., Liu, P., Nagamatsu, T., & Tong, Y. (2009). Chinese medicines as a resource for liver fibrosis treatment. Chinese medicine, 4(1), 1-11.
34. Chaudhari, V. M., &Kokate, K. K. A COMPREHENSIVE REVIEW OF DARUHARIDRA. International Journal of Research in Ayurveda and Medical Sciences, 1, 153-159.
35. Shailasree, S., Ruma, K., Kini, K. R., Niranjana, S. R., & Prakash, H. S. (2012). Potential anti-inflammatory bioactives from medicinal plants of Western Ghats, India. PharmacognCommun, 2(2), 71-7.
36. Chang, W., Chen, L., & Hatch, G. M. (2015). Berberine as a therapy for type 2 diabetes and its complications: from mechanism of action to clinical studies. Biochemistry and cell biology, 93(5), 479-486
37. Vuddanda, P. R., Chakraborty, S., & Singh, S. (2010). Berberine: a potentialphytochemical with multispectrum therapeutic activities. Expert opinion on investigational drugs, 19(10), 1297-1307.
38. Singh, M., Srivastava, S., &Rawat, A. K. S. (2007). Antimicrobial activities of Indian Berberis species. Fitoterapia, 78(7-8), 574-576.
39. Malik, F., Mirza, T., Riaz, H., Hameed, A., &Hussain, S. (2010). Biological screening of seventeen medicinal plants used in the traditional systems of medicine in Pakistan for antimicrobial activities. African Journal of Pharmacy and Pharmacology, 4(6), 335-340.
40. Padma, D., Pooja, G., & Ravi, S. (2009). In vitro and in vivo efficacy of a herbal formulation against skin infections. Journal of Pure and Applied Microbiology, 3(1), 199-204.
41. Sharma, R. S., Mishra, V., Singh, R., Seth, N., &Babu, C. R. (2008). Antifungal activity of some Himalayan medicinal plants and cultivated ornamental species. Fitoterapia, 79(7-8), 589-591.
42. Joshi, P. V., Shirkhedkar, A. A., Prakash, K., &Maheshwari, V. L. (2011). Antidiarrheal activity, chemical and toxicity profile of Berberisaristata. Pharmaceutical biology, 49(1), 94-100.
43. Sack, R. B., & Froehlich, J. L. (1982). Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxins. Infection and immunity, 35(2), 471-475.
44. Sabir, M., Akhter, M. H., &Bhide, N. K. (1977). Antagonism of cholera toxin by berberine in the gastrointestinal tract of adult rats. Indian journal of medical research, 65(3), 305-313.
45. Upwar, N., Patel, R., Waseem, N., &Mahobia, N. K. (2010). Pharmacognostic Evaluation of stem of Berberisaristata DC. Pharmacognosy Journal, 2(17), 5-9.
46. Goli, D. (2007). Anti-diabetic activity of stem bark of Berberisaristata DC in alloxan induced diabetic rats (Doctoral dissertation, RGUHS).
47. Wasana, K. G. P., Attanayake, A. P., Jayatilaka, K. A. P. W., &Weerarathna, T. P. (2020). Natural drug leads as novel DPP-IV inhibitors targeting the management of type 2 diabetes mellitus. Journal of Complementary Medicine Research, 11(1), 43-53.
48. Das, S., Das, M. K., Mazumder, P. M., Das, S., &Basu, S. P. (2009). Cytotoxic activity of methanolic extract of Berberis aristata DC on colon cancer. Global Journal of Pharmacology, 3(3), 137-140.
49. Mazumder, P. M., Das, S., Das, S., & Das, M. K. (2010). Cytotoxic activity of methanolic extracts of Berberis aristata DC and Hemidesmusindicus R. Br. MCF7 Cell Line. Journal of Current Pharmaceutical Research 2010; 1: 12, 15.
50. Anis, K. V., Rajeshkumar, N. V., &Kuttan, R. (2001). Inhibition of chemical carcinogenesis by berberine in rats and mice. Journal of Pharmacy and Pharmacology, 53(5), 763-768.
51. Anis, K. V., Rajeshkumar, N. V., &Kuttan, R. (2001). Inhibition of chemical carcinogenesis by berberine in rats and mice. Journal of Pharmacy and Pharmacology, 53(5), 763-768.
52. Patel, J., Aneja, K., & Tiwari, R. (2010). A review on bioavailability and bioequivalence trials and its necessity. Int J Pharmacy Pharm Sci, 2(3), 1-8.
53. Tripathi, Y. B., & Shukla, S. D. (1996). Berberisaristata inhibits PAF inducedaggregation of rabbit platelets. Phytotherapy Research, 10(7), 628-630.
54. Shah, B. H., Nawaz, Z., Saeed, S. A., &Gilani, A. H. (1998). Agonist‐ dependent differential effects of berberine in human platelet aggregation. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 12(S1), S60-S62.
55. Gilani, A. H., Janbaz, K. H., Aziz, N., Herzig, M. J., Kazmi, M. M., Choudhary, M. I., &Herzig, J. W. (1999). Possible mechanism of selective inotropic activity of the n-butanolic fraction from Berberisaristata fruit. General Pharmacology: The Vascular System, 33(5), 407-414.
56. Razzaq, F. A., Khan, R. A., Feroz, Z., &Afroz, S. (2011). Effect of Berberisaristata on lipid profile and coagulation parameters. African Journal of Pharmacy and Pharmacology, 5(7), 943-947.
2. N.Srikanth, The Actions and uses of Indigenous Ophthalmic Drugs, Chokhambha Sanskrit Prathisthan, Delhi, 2000.
3. J.P.N. Chanssuria, Studies on wound healing and effect of indigenous drugs on it., 1975; 198.
4. Dhar, M.L. et al, Screening of plants for biological activity part-1, Indian J. Exptl. Biol., 1968; 6: 232.
5. Shinwari, Z. K. (2010). Medicinal plants research in Pakistan. Journal of medicinal plants research, 4(3), 161- 176.
6. Muralidhar, C. V., &Kiran, K. K. (2018) A COMPREHENSIVE REVIEW OF DARUHARIDRA (BerberisAristata).
7. Komal, S., Ranjan, B., Neelam, C., Birendra, S., & Kumar, S. N. (2011). Berberisaristata: A review. Int J Res Ayurveda Pharm, 2(2), 383-388.
8. Chaudhari, V. M., & Kokate, K. K. A COMPREHENSIVE REVIEW OF DARUHARIDRA. International Journal of Research in Ayurveda and Medical Sciences, 1, 153-159.
9. Dravyaguna Hastamlaka by Vaidya Banwari Lal Misra edited by Vaidya Santosh Kumar Sharma Khandal published by Publication Scheme revised 5th edition, 437.
10. Khory, R. N., &Katrak, N. N. (1903). MateriaMedica of India and their therapeutics. Caxton Works.
11. Berberis [home page on internet] [cited on 2010 Sep 15] available on http://en.wikipedia.org/wiki/Berberis
12. Parmar, C., &Kaushal, M. K. (1982). Berberisaristata: Wild fruits. Kalyani Publishing Ludhiana, 10-14.
13. Kala, C. P., Dhyani, P. P., &Sajwan, B. S. (2006). Developing the medicinal plants sector in northern India: challenges and opportunities. Journal of Ethnobiology and Ethnomedicine, 2(1), 1-15.
14. Malairajan, P., Gopalakrishnan, G., Narasimhan, S., &Veni, K. J. K. (2006). Analgesic activity of some Indian medicinal plants. Journal of ethnopharmacology, 106(3), 425-428.
15. Parmar C and Kaushal MK. Berberisaristata: Indian: Wild Fruits. Kalyani Publishers, New Delhi, India. 1982; 10–14.
16. Rashmi, Rajasekaran A, Pant Jagdish. The genus berberis Linn: a review. Pharmacognosy review 2008 Jul-dec; 2(4):368-385.
17. Chakravarti, K. K., Dhar, D. C., & Siddiqui, S. (1950). Alkaloidalconsistuents of the bark ofBerberisaristata. Journal of Scientific and Industrial Research, (7), 161-4
18. Blasko, G., Murugesan, N., Freyer, A. J., Shamma, M., & Ansari, A. A. (1982). Karachine: an unusual protoberberine alkaloid. Journal of the American Chemical Society, 104(7), 2039-2041.
19. RAHMAN, A., & Ansari, A. A. (2011). Alkaloids of Berberisaristata-isolation of aromoline and oxyberberine. Journal of The Chemical Society of Pakistan, 5(4), 283.
20. Saied, S., &Batool, S. (2007). ShaistaNaz, Phytochemical studies of Berberisaristata, J. Basic Appl. Sci, 3(1), 1-3.
21. Blasko, G., ANSARI, A. A., & RAHMAN, A. U. (1982). Taxilamine, a pseudobenzylisoquinoline alkaloid.
22. Sivakumar, R., & KAMACHANDRAN NAIR, A. G. (1991). Polyphenolic constituents of the flowers of Berberisaristata. Journal of the Indian Chemical Society, 68(9), 531-532.
23. Sivakumar, R., & KAMACHANDRAN NAIR, A. G. (1991). Polyphenolic constituents of the flowers of Berberisaristata. Journal of the Indian Chemical Society, 68(9), 531-532.
24. Katiyar, D., Singh, R. K., Singh, S., Singh, D., & Singh, V. (2011). Isolation and characterization of ndocosane from heartwood of Berberisaristata. International Journal of Pharmaceutical Sciences and Research, 2(2), 331.
25. Kasture, V. S., &Gharate, M. K. (2011). SIMPLE AND RAPID SCHEME OF STANDARDIZATION OF LOHASAVA. international Journal of Ayurvedic and Herbal Medicine, 1(03)
26. Sharma PV. Darvayaguna Vigyan Vol-II, Published by Choukhambha Bharti academy, Varanasi, Reprint 1998 pg. 539
27. Pandey, G. (2004). Dravyagunavijnana. Part III, ChowkhambaKrishnadas Academy, Varanasi (Reprint), 852.
28. J.P.N. Chanssuria, Studies on wound healing and effect of indigenous drugs on it., 1975; 198.
29. WebMD.Tree-turmeric: Uses, Side effects, Doses, Interactions [Internet].Atlanta [last updated in 2016].
30. Sohni, Y. R., & Bhatt, R. M. (1996). Activity of a crude extract formulation in experimental hepatic amoebiasis and in immunomodulation studies. Journal of ethnopharmacology, 54(2-3), 119-124.
31. Gilani, A. U., &Janbaz, K. H. (1995). Studies on protective effect of Cyperusscariosus extract on acetaminophen and CCl4-inducedhepatotoxicity. General pharmacology, 26(3), 627-631.
32. Tsai, P. L., & Tsai, T. H. (2004). Hepatobiliary excretion of berberine. Drug Metabolism and Disposition, 32(4), 405-412.
33. Feng, Y., Cheung, K. F., Wang, N., Liu, P., Nagamatsu, T., & Tong, Y. (2009). Chinese medicines as a resource for liver fibrosis treatment. Chinese medicine, 4(1), 1-11.
34. Chaudhari, V. M., &Kokate, K. K. A COMPREHENSIVE REVIEW OF DARUHARIDRA. International Journal of Research in Ayurveda and Medical Sciences, 1, 153-159.
35. Shailasree, S., Ruma, K., Kini, K. R., Niranjana, S. R., & Prakash, H. S. (2012). Potential anti-inflammatory bioactives from medicinal plants of Western Ghats, India. PharmacognCommun, 2(2), 71-7.
36. Chang, W., Chen, L., & Hatch, G. M. (2015). Berberine as a therapy for type 2 diabetes and its complications: from mechanism of action to clinical studies. Biochemistry and cell biology, 93(5), 479-486
37. Vuddanda, P. R., Chakraborty, S., & Singh, S. (2010). Berberine: a potentialphytochemical with multispectrum therapeutic activities. Expert opinion on investigational drugs, 19(10), 1297-1307.
38. Singh, M., Srivastava, S., &Rawat, A. K. S. (2007). Antimicrobial activities of Indian Berberis species. Fitoterapia, 78(7-8), 574-576.
39. Malik, F., Mirza, T., Riaz, H., Hameed, A., &Hussain, S. (2010). Biological screening of seventeen medicinal plants used in the traditional systems of medicine in Pakistan for antimicrobial activities. African Journal of Pharmacy and Pharmacology, 4(6), 335-340.
40. Padma, D., Pooja, G., & Ravi, S. (2009). In vitro and in vivo efficacy of a herbal formulation against skin infections. Journal of Pure and Applied Microbiology, 3(1), 199-204.
41. Sharma, R. S., Mishra, V., Singh, R., Seth, N., &Babu, C. R. (2008). Antifungal activity of some Himalayan medicinal plants and cultivated ornamental species. Fitoterapia, 79(7-8), 589-591.
42. Joshi, P. V., Shirkhedkar, A. A., Prakash, K., &Maheshwari, V. L. (2011). Antidiarrheal activity, chemical and toxicity profile of Berberisaristata. Pharmaceutical biology, 49(1), 94-100.
43. Sack, R. B., & Froehlich, J. L. (1982). Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxins. Infection and immunity, 35(2), 471-475.
44. Sabir, M., Akhter, M. H., &Bhide, N. K. (1977). Antagonism of cholera toxin by berberine in the gastrointestinal tract of adult rats. Indian journal of medical research, 65(3), 305-313.
45. Upwar, N., Patel, R., Waseem, N., &Mahobia, N. K. (2010). Pharmacognostic Evaluation of stem of Berberisaristata DC. Pharmacognosy Journal, 2(17), 5-9.
46. Goli, D. (2007). Anti-diabetic activity of stem bark of Berberisaristata DC in alloxan induced diabetic rats (Doctoral dissertation, RGUHS).
47. Wasana, K. G. P., Attanayake, A. P., Jayatilaka, K. A. P. W., &Weerarathna, T. P. (2020). Natural drug leads as novel DPP-IV inhibitors targeting the management of type 2 diabetes mellitus. Journal of Complementary Medicine Research, 11(1), 43-53.
48. Das, S., Das, M. K., Mazumder, P. M., Das, S., &Basu, S. P. (2009). Cytotoxic activity of methanolic extract of Berberis aristata DC on colon cancer. Global Journal of Pharmacology, 3(3), 137-140.
49. Mazumder, P. M., Das, S., Das, S., & Das, M. K. (2010). Cytotoxic activity of methanolic extracts of Berberis aristata DC and Hemidesmusindicus R. Br. MCF7 Cell Line. Journal of Current Pharmaceutical Research 2010; 1: 12, 15.
50. Anis, K. V., Rajeshkumar, N. V., &Kuttan, R. (2001). Inhibition of chemical carcinogenesis by berberine in rats and mice. Journal of Pharmacy and Pharmacology, 53(5), 763-768.
51. Anis, K. V., Rajeshkumar, N. V., &Kuttan, R. (2001). Inhibition of chemical carcinogenesis by berberine in rats and mice. Journal of Pharmacy and Pharmacology, 53(5), 763-768.
52. Patel, J., Aneja, K., & Tiwari, R. (2010). A review on bioavailability and bioequivalence trials and its necessity. Int J Pharmacy Pharm Sci, 2(3), 1-8.
53. Tripathi, Y. B., & Shukla, S. D. (1996). Berberisaristata inhibits PAF inducedaggregation of rabbit platelets. Phytotherapy Research, 10(7), 628-630.
54. Shah, B. H., Nawaz, Z., Saeed, S. A., &Gilani, A. H. (1998). Agonist‐ dependent differential effects of berberine in human platelet aggregation. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 12(S1), S60-S62.
55. Gilani, A. H., Janbaz, K. H., Aziz, N., Herzig, M. J., Kazmi, M. M., Choudhary, M. I., &Herzig, J. W. (1999). Possible mechanism of selective inotropic activity of the n-butanolic fraction from Berberisaristata fruit. General Pharmacology: The Vascular System, 33(5), 407-414.
56. Razzaq, F. A., Khan, R. A., Feroz, Z., &Afroz, S. (2011). Effect of Berberisaristata on lipid profile and coagulation parameters. African Journal of Pharmacy and Pharmacology, 5(7), 943-947.
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Patel R, Priyadarshi S, Kushwaha AK. Daruharidra (Berberisaristata Dc.) An Important Ayurvedic Medicinal Plant - A Review. World Journal of Current Med and Pharm Research [Internet]. 2023Oct.8 [cited 2024Sep.19];5(5):219-23. Available from: https://wjcmpr.com/index.php/journal/article/view/296
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