General overview of the Risk factors, Pathogenesis, and Combined treatments for Hashimoto's Thyroiditis (HT)

  • Yash Srivastav Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India.
  • Akhandnath Prajapati Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India.
  • Meera Kumari Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India.
  • Madhaw Kumar Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India.


In regions of the world where iodine is abundant, Hashimoto's thyroiditis, also known as Hashimoto's disease or autoimmune thyroiditis, is the most prevalent cause of hypothyroidism. It is a chronic inflammation of the thyroid gland. It is characterized by autoimmune-mediated thyroid gland destruction, which results in progressive thyroid failure, either with or without goiter formation. In young to middle-aged women, Hashimoto's thyroiditis typically starts as a painless, diffuse, firm thyroid gland enlargement that progresses to hypothyroidism. Many people don't initially exhibit hypothyroidism, and some don't even have a goiter or may have an atrophic thyroid gland. Hashimoto's thyroiditis (HT), also known as chronic autoimmune thyroiditis, is an inflammatory condition that is characterized by parenchymal atrophy, fibrosis, and diffuse lymphocytic infiltration. being the main source of primary hypothyroidism in regions with adequate iodine. With the help of various criteria, such as physical examination, blood tests for thyroid hormone levels (TSH is low, T3 and T4 are tall, for example), serum cholesterol and triglycerides, blood glucose, and radioactive iodine uptake, it is possible to distinguish between infections and clutter. According to estimates from several thyroid disease studies, 42 million persons in India are estimated to have the ailment. The pathogenesis causes, risk factors and combination therapy linked to Hashimoto's thyroiditis are discussed in this review study.

Keywords: Hashimoto's thyroiditis, Etiology, Epidemiology, Risk factors, Signs and Symptoms, Pathophysiology, Treatments


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Author Biographies

Yash Srivastav, Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India.

Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India.

Akhandnath Prajapati, Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India.

Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India.

Meera Kumari, Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India.

Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India.

Madhaw Kumar, Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India.

Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India.


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Srivastav, Y., A. Prajapati, K. Meera, and K. Madhaw. “General Overview of the Risk Factors, Pathogenesis, and Combined Treatments for Hashimoto’s Thyroiditis (HT)”. World Journal of Current Medical and Pharmaceutical Research, Vol. 5, no. 5, Sept. 2023,
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