Combinational Effect of Andrographis paniculata, Azadirachta indica and Carica papaya latex for Anthelmintic Potential on Pontoscolex corethrurus
Abstract
The present study was done with the aim to screen the anthelmintic activity of decoction containing Andrographis paniculata (Kalmegh), Azadirachta indica (Neem), Carica papaya latex using Pontoscolex corethrurus. The different concentrations (40%, 60% and 80%) of decoction were evaluated for determining the time of paralysis and the time of death of earthworms. Albendazole (10mg/ml) used as standard reference and normal saline as control. The data of the study revealed that the decoction at 80% concentration showed better anthelmintic activity compared to standard drug Albendazole.
Keywords:
Anthelmintic activity, Andrographis paniculata, Carica papaya latex, Decoction, Pontoscolex corethrurus
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2. Padma Y, Narasimhudu CL, Devi S, Natha NM, Naga RB, Philip GH. In vitro anthelmintic activity of Andrographis paniculata (burm. f.) nees. International Journal of Pharmaceutical Research and Developement. 2011;3(3):202-5.
3. Padma Y, Sarojini Devi N, Manjunatha B, Philip GH, VenkataRaju RR. Preliminary phytochemical screening and anthelmintic activity of Andrographis echioides Nees. J Pharm Res. 2012;5(9):4801e4803.
4. Dwivedi A, Dwivedi S, Sitoke AK, Patel R, Jhade D. Anthelmintic activity of a polyherbal preparation. Ethnobotanical Leaflets. 2009;2009(1):33.
5. Tamboli FA, More HN. Anthelmintic activity of leaves extract of Barleria gibsoni Dalz. against Pheretima posthuma. Journal of Pharmacognosy and Phytochemistry. 2016 Jan 1;5(1):250.
6. Siddhartha S, Archana M, Jinu J, Pradeep M. Anthelmintic potential of Andrographis paniculata, Cajanus cajan and Silybum marianum. Pharmacogn J. 2009 Dec 1;1:243.
7. Rajeswari VD. Anthelmintic activity of plants: a review. Res J Phytochem. 2014;8(3):57-63.
8. Akbar S. Andrographis paniculata: a review of pharmacological activities and clinical effects. Alternative Medicine Review. 2011 Mar 1;16(1):66-77.
9. Hashim N, Abdullah S, Hassan LS, Ghazali SR, Jalil R. A study of neem leaves: Identification of method and solvent in extraction. Materials Today: Proceedings. 2021 Jan 1;42:217-21.
10. Macalood JS, Vicente HJ, Boniao RD, Gorospe JG, Roa EC. Chemical analysis of Carica papaya L. crude latex. American Journal of Plant Sciences. 2013 Sep 25;4(10):1941.
11. Urgessa OE, Itana DD, Raga TO. Extraction of Papain from Papaya (Carica papaya L.) Fruit Latex and Its Application in Transforming Tannery Raw Trimming. Ethiopian Journal of Sciences and Sustainable Development. 2019 Sep 9;6(2):22-32.
12. Shaikh JR, Patil MK. Qualitative tests for preliminary phytochemical screening: An overview. International Journal of Chemical Studies. 2020 Mar;8(2):603-8.
13. Patel AV, Patel AV, Bharadiya PD, Patel NM. A Study on Evaluation of Anthelmintic Activity of Leaves Extract of Tephrosea purpurea (Linn). Inventi Rapid: Ethnopharmacology. 2011 Sep 6;3(5).
Published
05-11-2022
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Shilpashree V. K., N. Velip, D. Gaonkar, G. Kundaikar, C. Gaude, H. R. C. Poojari, and R. Nayak. “Combinational Effect of Andrographis Paniculata, Azadirachta Indica and Carica Papaya Latex for Anthelmintic Potential on Pontoscolex Corethrurus”. World Journal of Current Medical and Pharmaceutical Research, Vol. 4, no. 5, Nov. 2022, pp. 139-42, doi:10.37022/wjcmpr.v4i5.238.
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