A A review on role of neuromodulators in autism spectrum disorder
Abstract
Autism spectrum disorder (ASD) is a group of complex neurodevelopmental disorders whose diagnosis is exclusively made on a behavioral basis. According to the diagnostic and statistical manual of mental disorders, autism is defined by deficits in two main symptoms (social interaction & communication, and repetitive/restrictive behaviors), which emerge in premature phases of postnatal development. The authors review evidence that ASD is a neurobiological disorder influenced by both genetic and environmental factors affecting the developing brain, and enumerate factors that correlate with ASD risk. Finally, the article describes how clinical evaluation begins with developmental screening.
Keywords:
Autism, Social Behaviour, Neuromodulators
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References
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2. Avital, A., Mizrachi, S.A. and Zubedat, S. (2016). Evidence for social cooperation in rodents by automated maze. Scientific Reports. 6; 29517: 1
3. Berg, W.E., et al. (2014). Sex specific mechanism of social hierarchy in mice. Neuropsychopharmacology. 1-9.
4. Bergan, J.F. (2015). Neural computation and neuromodulation underlying social Behavior. Integrative and Comparative Biology. 1-13.
5. Donaldson, T.N., et.al. (2017). Social order: Using the sequential structure of social interaction to discriminate abnormal social behavior in the rat. Learning and Motivation. 1505: 1.
6. Insel, T.R. (2010). The challenge of translation in social neuroscience: A review of oxytocin, vasopressin, and affiliative behavior. Neuron 65: 768-779.
7. Johnson, Z.V. and Young, L.J. (2017). Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience. Neuroscience and Biobehavioral Reviews. 76: 87-98.
8. Karvat, G. and Kimchi, T. (2014). Acetylcholine elevation relieves cognitive rigidity and social deficiency in a mouse model of autism. Neuropsychopharmacology. 39: 831-840.
9. Kim, K.C., et al. (2016). Clinical and neurobiological relevance of current animal models of autism spectrum disorders. Biomol Ther. 24(3): 207-243.
10. Liu, Q., Shi, J., Lin, R. and Wen, T. (2017). Dopamine and dopamine receptor D1 associated with decreased social interaction. Behavioural Brain Research. 324: 51-57.
11. Opendak, M., et al. (2016). Social behavior, hormones and adult neurogenesis. Frontiers in Neuroendocrinology. 1-60.
12. Parashar, A. and Malairaman, U. (2015). Gut microbiota regulates key modulators of social behavior. European Neuropsychopharmacology. 1-48.
13. Pitesa, M., et al. (2013). Cognitive control and socially desirable behavior: The role of interpersonal impact. Organizational Behavior and Human Decision Processes. 122: 232-243.
14. Provenzanoa, G., Chelinia, G. and Bozzia, Y. (2016). Genetic control of social behavior: Lessons from mutant mice. Behavioural Brain Research. 10545: 1-14.
15. Sejourne, J., Llaneza, D., Kuti, O.J. and Page, D.T. (2015). Social behavioral deficits coincide with the onset of seizure susceptibility in mice lacking serotonin receptor 2c. 5-HT2cR and development of social behavior. PLOS ONE. 10(8): 0136494.
16. Steenbergen, L., Jongkees, B.J., Sellaro, R. and Colzato, L.S. (2016). Tryptophan supplementation modulates social behavior: a review. Neuroscience and Biobehavioral Reviews. 2376: 1-49.
17. Wei, D., Allsop, S., Tye, K. and Piomelli, D. (2017). Endocannabinoid signaling in the control of social behavior. Trends in Neurosciences. 1310: 1-12.
18. Zahn, R., et al. (2017). Frontotemporal lobar degeneration and social behaviour: dissociation between the knowledge of its consequences and its conceptual meaning. Cortex. 1-37.
Published
03-10-2022
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How to Cite
Hussain, S., and F. Deeba. “A A Review on Role of Neuromodulators in Autism Spectrum Disorder”. World Journal of Current Medical and Pharmaceutical Research, Vol. 4, no. 5, Oct. 2022, pp. 103-9, doi:10.37022/wjcmpr.v4i5.228.
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Review Articles
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