Review on obsessive-compulsive disorder
Abstract
OCD is a syndrome characterized by obsessions and compulsions, as well as other neuropsychiatric features, and is often associated with primary psychiatric disorders and various neurologic conditions. If severe, OCD can seriously interfere with the patient’s quality of life. The mainstay of treatment is psychotherapy, especially cognitive-behavioural therapy, and pharmacologic interventions, especially selective serotonin reuptake inhibitors (SSRIs). Unfortunately, a significant proportion of patients are refractory to these treatment modalities. A new understanding abuts the neurobiology of OCD has led to novel investigational treatments, especially neuromodulation techniques.
Keywords:
obsessions, compulsions, selective serotonin reuptake inhibitors, cognitive-behavioural therapy
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References
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2. Townsend Mary.C. psychyiatric mental health nursing concepts of care. 5 edition. F. a. davis company publishers. Philadelphia USA. P 449-454.
3. Flament MF, Whitaker A, Rapoport JL, et al. Obsessive compulsive disorder in adolescence: an epidemiological study. J Am Acad Child Adolesc Psychiatry 1988;27:764–71.
4. Heyman I, Fombonne E, Simmons H, et al. Prevalence of obsessive—compulsive disorder in the British nationwide survey of child mental health. Br J Psychiatry 2001;179:324–9.
5. Douglass HM, Moffitt TE, Dar R, et al. Obsessive-compulsive disorder in a birth cohort of 18-year-olds: prevalence and predictors. J Am Acad Child Adolesc Psychiatry 1995;34:1424–31.
6. Skoog G, Skoog I. A 40-year follow-up of patients with obsessive-compulsive disorder. Arch Gen Psychiatry 1999;56:121–7.
7. Stewart S, Geller D, Jenike M, et al. Long-term outcome of pediatric obsessive compulsive disorder: a meta-analysis and qualitative review of the literature. Acta Psychiatr Scand 2004;110:4–13.
8. Piacentini J, Bergman RL, Keller M, et al. Functional impairment in children and adolescents with obsessive-compulsive disorder. J Child Adolesc Psychopharmacol 2003;13(2, Supplement 1):61–9.
9. Wewetzer C, Jans T, Muller B, et al. Long-term outcome and prognosis of obsessive-compulsive disorder with onset in childhood or adolescence. Eur Child Adolesc Psychiatry 2001;10:37–46.
10. Micali N, Heyman I, Perez M, et al. Long-term outcomes of obsessive–compulsive disorder: follow-up of 142 children and adolescents. Br J Psychiatry 2010;197:128–34.
11. Pauls DL. The genetics of obsessive compulsive disorder: a review of the evidence.Am J Med Genet C Semin Med Genet 2008;148C:133–9.
12. van Grootheest DS, Cath DC, Beekman AT, et al. Twin studies on obsessive–compulsive disorder: a review. Twin Res Hum Genet 2005;8:450–58.
13. Eley TC, Bolton D, O’Connor TG, et al. A twin study of anxiety-related behaviours in pre-school children. J Child Psychol Psychiatry 2003;44:945–60.
14. Stewart SE, Yu D, Scharf JM, et al. Genome-wide association study of obsessive-compulsive disorder. Mol Psychiatry 2013;18:788–98.
15. Mattheisen M, Samuels JF, Wang Y, et al. Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. Mol Psychiatry 2014.
16. Taylor S. Molecular genetics of obsessive-compulsive disorder: a comprehensive meta-analysis of genetic association studies. Mol Psychiatry 2013;18:799–805.
17. Pauls DL, Abramovitch A, Rauch SL, et al. Obsessive-compulsive disorder: an integrative genetic and neurobiological perspective. Nat Rev Neurosci 2014;15:410–24.
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31-05-2022
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Gorre VN, Shaik K, Pothavarapu T, Kaki SS, Shaik S, Vinodula SS. Review on obsessive-compulsive disorder. World Journal of Current Med and Pharm Research [Internet]. 2022May31 [cited 2025May18];4(3):45-7. Available from: https://wjcmpr.com/index.php/journal/article/view/216
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