Formulation and evaluation of oral disintegrating tablets of furosemide

Formulation of ODTs of Furosemide

  • Manish Khadka Department of Pharmacy, Manmohan Memorial Institute of Health Sciences, Tribhuvan University, Soalteemode-44600, Kathmandu, Nepal
  • Dharma Prasad Khanal Department of Pharmacy, Manmohan Memorial Institute of Health Sciences, Tribhuvan University, Soalteemode-44600, Kathmandu, Nepal
  • Deepti Piya Baniya Department of Pharmacy, Manmohan Memorial Institute of Health Sciences, Tribhuvan University, Soalteemode-44600, Kathmandu, Nepal
  • Prakash Karki Department of Pharmacy, Manmohan Memorial Institute of Health Sciences, Tribhuvan University, Soalteemode-44600, Kathmandu, Nepal
  • Saurav Shrestha Department of Pharmacy, Institute of Medicine, Maharajgunj Medical Campus, Tribhuvan University, Maharajgunj-44600, Kathmandu, Nepal

Abstract

Orally disintegrating tablets of Furosemide were prepared, evaluated and the comparison of the action of different concentrations of disintegrants on disintegration and dissolution of the tablets were studied. Direct compression method was used to prepare the orally disintegrating tablets containing 20 mg of Furosemide. The formulation was conducted using different concentrations of crospovidone, croscarmellose and sodium starch glycolate as superdisintegrants and their interactions with Furosemide were also evaluated using FTIR.  FTIR studies using the drug and its mixtures with the excipients showed that the peaks correlate with one another which signify that there is no interaction between the drug molecule and the excipients used. The obtained results revealed that the disintegration time of ODTs were between 9 to 59 seconds. The percentage drug content of tablets in all the formulations was found between 91.51% to 106.69%, which complies with the limits established in pharmacopoeia. The in-vitro dissolution studies show maximum release of 89.47% in formulation F3 and minimum of 77.64% in formulation F12. Higher concentration of crospovidone and croscarmellose in formulations F3 and F6 showed better dissolution properties than SSG. So by varying the concentrations of superdisintegrants, oral disintegrating tablets can be formulated.

Keywords: Orally disintegrating tablet, Superdisintegrants, Furosemide, FTIR

Downloads

Download data is not yet available.

References

1. Abay FB, Ugurlu T. Orally Disintegrating Tablets: A Short Review. Journal of Pharmaceutics and Drug Development. 2015;3:3-303.
2. Tejas K, Ganesh D. A Review on Orodispersible Tablets: A Novel Approach. Research Journal of Pharmacy and Technology. 2019;12:8-3993.
3. Babu A, Akhtar M. Overview of formulation and evaluation of fast dissolving tablet: A promising tablet dosage form. Journal of Applied Pharmaceutical Research. 2020;8:3.
4. Hirani J, Rathod D, Vadalia K. Orally Disintegrating Tablets: A Review. Tropical Journal of Pharmaceutical Research. 2009;8:2.
5. Shende M, Chavan K. Formulation of Furosemide Oral Disintegrating Tablets Using Natural and Synthetic Superdisintegrants by SeDeM Expert Design System. Journal of Drug Delivery and Therapeutics. 2019;9:6.
6. Shariare M, Altamimi M, Marzan A, Tabassum R, Jahan B, Reza H et al. In vitro dissolution and bioavailability study of furosemide nanosuspension prepared using design of experiment (DoE). Saudi Pharmaceutical Journal. 2019;27:1.
7. Hao T. Understanding empirical powder flowability criteria scaled by Hausner ratio or Carr index with the analogous viscosity concept. RSC Advances. 2015;5:70.
8. Naveed S, Qamar F. Simple UV spectrophotometric assay of Furosemide. Journal of Innovations in Pharmaceuticals and Biological Sciences. 2014;01:06.
9. Bharate SS, Bharate SB, Bajaj AN. Interactions and incompatibilities of pharmaceutical excipients with active pharmaceutical ingredients: a comprehensive review. Journal of Excipients and Food Chemicals 2011;42:47.
10. Desai P, Liew C, Heng P. Review of Disintegrants and the Disintegration Phenomena. Journal of Pharmaceutical Sciences. 2016;105:9.
11. Nagoba Shivappa, Warkari Rajan, Shimge Krishna, Gaikwad V. Formulation and Evaluation of Furosemide Oral Disintegrating Tablets. International Journal of Pharmaceutical Science Invention 2018;23:19.
12. T.Gulsun, N.Ozturk, M.S. Kaynak, I.Vural, S.Sahin. Preparation and evaluation of furosemide containing orally disintegrating tablets by direct compression. International Journal of Pharmaceutical Sciences 2017;38:9.
13. Tarannum, Dr. Shahid Mohammed, Formulation and evaluation of Furosemide oral dispersible tablets. International Journal of Farmacia 2015;1:02-91.
14. Yassin S, Goodwin D, Anderson A, Sibik J, Ian Wilson D, Gladden L et al. The Disintegration Process in Microcrystalline Cellulose Based Tablets, Part 1: Influence of Temperature, Porosity and Superdisintegrants. Journal of Pharmaceutical Sciences. 2015; 104:10:3440-3450.
Published
07-12-2021
Statistics
1076 Views | 606 Downloads
Citatons
How to Cite
1.
Khadka M, Khanal DP, Baniya DP, Karki P, Shrestha S. Formulation and evaluation of oral disintegrating tablets of furosemide: Formulation of ODTs of Furosemide. World Journal of Current Med and Pharm Research [Internet]. 2021Dec.7 [cited 2025Apr.26];3(6):149-56. Available from: https://wjcmpr.com/index.php/journal/article/view/200
Section
Research Articles