Formulation development and evaluation of duloxetine extended-release tablets

  • Ch.Saibabu Head , Department of Pharmaceutics, M.L. College of Pharmacy, S. Konda-523101
    saichennupalli@gmail.com
  • M.Naresh Department of Pharmaceutics, M.L. College of Pharmacy, S. Konda-523101
  • K.Sirisha Department of Pharmaceutics, M.L. College of Pharmacy, S. Konda-523101
  • R.vineetha Department of Pharmaceutics, M.L. College of Pharmacy, S. Konda-523101
  • P.Sai Kumar Department of Pharmaceutics, M.L. College of Pharmacy, S. Konda-523101
  • K.Deepika Department of Pharmaceutics, M.L. College of Pharmacy, S. Konda-523101
  • Sk.Karishma Department of Pharmaceutics, M.L. College of Pharmacy, S. Konda-523101

Abstract

Duloxetine  is an anti-depressant drug which is used in depression. The aim of present investigation was to prepare an ER tablet of duloxetine with similar dissolution profile matching to Effexor ER. An immediate release core tablet of 100mg was prepared and it was compression coated using HPMC matrix system. HPMC of three viscosity grades i.e., K4M, K15M, K100M and different concentrations of 15% polymer, 25% polymer, 35% polymer & 45% polymer were taken. With the above polymers by using wet granulation and direct compression process 11 formulations were prepared. The data obtained from in vitro drug release was used to determine the similarity factor between marketed and optimized product. Out of all F11 formulation (K15M 35% polymer) is optimized and is matching with the marketed product.

Keywords: Duloxetine Extended release tablet, Compression coating method

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Published
30-06-2021
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How to Cite
Ch, S., N. M, S. K, vineetha R, S. K. P, D. K, and K. Sk. “Formulation Development and Evaluation of Duloxetine Extended-Release Tablets ”. World Journal of Current Medical and Pharmaceutical Research, Vol. 3, no. 3, June 2021, pp. 62-67, doi:10.37022/wjcmpr.vi.178.
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Research Articles