Formulation and Evaluation of Orally Disintegrating Tablet of Metoclopramide Hydrochloride

  • Sujan Dawadi Asian College for Advance Studies, Purbanchal University
  • Bipindra Pandey School of Health and Allied Science, Pokhara University
    bipindra.p101@gmail.com
  • Sabina Nepal Asian College for Advance Studies, Purbanchal University
  • Yamuna Gurau Asian College for Advance Studies, Purbanchal University
  • Rashmi Shahi Asian College for Advance Studies, Purbanchal University
  • Bijay Gautam School of Health and Allied Sciences, Pokhara University
  • Deepak Akauliya Asian College for Advance Studies, Purbanchal University
  • Manoj Pandit Universal College of Medical Sciences, Tribhuvan University
  • Sailendra Chaudhary Asian College for Advance Studies, Purbanchal University
  • Chandrika Adhikari Mahat Asian College for Advance Studies, Purbanchal University

Abstract

Orally disintegrating drug delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the fastest, safest, convenient, and most economic method of drug delivery having the highest patient compliance and preferred over conventional tablets. The goal of this study was to formulate and evaluate oral disintegrating tablets (ODTs) of Metoclopramide hydrochloride to overcome swallowing difficulties. The key to developing successful ODT formulation by direct compression method is to select the right super disintegrant.  Nine formulations were prepared using different super disintegrants such as sodium starch glycolate (SSG), croscarmellose sodium (CCS), and crospovidone (CP) at three concentrations i.e. 2.8 %, 4 %, and 4.8 %. The formulation was evaluate for pre and post-compression parameters like angle of repose, compressibility index, Hausner's ratio, uniformity of content, thickness, hardness, friability, drug content, wetting time, water absorption ratio, dispersion time, in-vitro disintegration time etc. Results revealed that among the 9 formulations, the formulation MHF9 containing 4.8 % of crospovidone was selected as the best formulation as its wetting time 28 second, disintegration and dispersion time 7 second and 18 seconds, percentage drug release after 15 minutes was 102.52 %.

Keywords: Formulation, Orally disintegrating tablets, Metoclopramide Hydrochloride, Direct compression, Superdisintegrants

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Author Biographies

Sujan Dawadi, Asian College for Advance Studies, Purbanchal University

Scholar Student, Master of Pharmaceutical Sciences

Bipindra Pandey, School of Health and Allied Science, Pokhara University

Scholar Student, Master of Pharmaceutical Sciences

Sabina Nepal, Asian College for Advance Studies, Purbanchal University

Student, Bachelor of Pharmacy

Yamuna Gurau, Asian College for Advance Studies, Purbanchal University

Student, Bachelor of Pharmacy

Rashmi Shahi, Asian College for Advance Studies, Purbanchal University

Student, Bachelor of Pharmacy

Bijay Gautam, School of Health and Allied Sciences, Pokhara University

Student, Master of Pharmaceutical Sciences

Deepak Akauliya, Asian College for Advance Studies, Purbanchal University

Student, Bachelor of Pharmacy

Manoj Pandit, Universal College of Medical Sciences, Tribhuvan University

Lecturer, Department of Pharmacology

Sailendra Chaudhary, Asian College for Advance Studies, Purbanchal University

Lecturer, Department of Pharmacy

Chandrika Adhikari Mahat, Asian College for Advance Studies, Purbanchal University

Lecturer, Department of Pharmacy

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Published
15-12-2020
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Dawadi, S., Bipindra Pandey, S. Nepal, Y. Gurau, R. Shahi, B. Gautam, D. Akauliya, M. Pandit, S. Chaudhary, and C. Adhikari Mahat. “Formulation and Evaluation of Orally Disintegrating Tablet of Metoclopramide Hydrochloride”. World Journal of Current Medical and Pharmaceutical Research, Dec. 2020, pp. 322-9, doi:10.37022/wjcmpr.vi.162.
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Research Articles