ROLE OF CLINICAL PHARMACIST IN ASSESSMENT OF DRUG RELATED PROBLEMS OF CARDIO VASCULAR AGENTS IN DEPARTMENT OF CARDIOLOGY IN A TERTIARYCARE HOSPITAL – A PROSPECTIVE OBSERVATIONAL STUDY

  • Dr.S.Naga Subrahmanyam Assistant Professor, Department of Pharmacy Practice, Koringa College of Pharmacy, Korangi - 533461, Kakinada, A.P, India.
    subrahmanyamsatupati@gmail.com
  • Dr.D.Tagoore Vijaya Lakshmi Department of Pharmacy Practice, Chalapathi institute of Pharmaceutical Sciences, Guntur - 522004, A.P, India.
  • Dr.G.V. Nagaraju Assistant Professor, Department of Pharmacy Practice, Avanti institute of Pharmaceutical sciences, Tagarapuvalasa, Vizayanagaram Dist, A.P, India
  • Dr.G.V.Pavan Kumar Associate Professor, Department of Pharmaceutical Chemistry, Koringa College of Pharmacy, Korangi - 533461, Kakinada, A.P, India.

Abstract

In total, of 173 prescriptions of the patient the total number of 329 drug interaction was found in which the 240 interaction was found in male and 89 in the female bearing the 72.90% and 27.10% respectively. Patient was of various age groups in which the maximum frequency was seen in the age group of 61- 70 years having 105 interaction bearing the percentage of 31.9% . According to the participation of different age group of the male and female with their corresponding age .The participation of male is high having frequency of 240 (72.9% )than female participation of frequency 89 (27.1%).The participation of male in the age group of 61-70 years is 83 and the female is 40 in the age group of 51-60 years. Potential drug interactions were categorized based on the gender. In that compared to 13 (40.6) females, males 19 (59.4%) were found to have more potential drug interactions. Our study more potential drug interactions in adult patients. Because, in adults lacking of nutrition’s and in elderly patients multiple prescribers, multiple drugs and multiple diseases. The number of potential DDI increased with an increase in the number of drug prescribed. The numbers of drug prescribed increase with age .This drug interaction have a potential to increase or decrease the therapeutic effect or to increase the risk of ADR. An increased awareness of PDDIs , rational co –prescription of drugs and a close monitoring of patients in whom these drugs are prescribed is recommended .The recommendation is based on the special monitoring and the perspiration of the clinical pharmacist .The Drug interaction observed in the geriatric patient are more severe and common in compared to the other group of study. The geriatric patient are physiological disability in correspond with the first pass metabolism and the presence of the other disease which also enables the multiple prescription causing poly pharmacy. The gender specification also the cause of the interaction , the female are more prone to the drug interaction due to the hormonal distribution in the body and inability of the physiological function to absorb and the distribution .The special training should be provided to the pharmacist for looking forward of the geriatric patient and female patient .The training regarding the prescription their adherence ,use ,toxicity , dosage regimen ,are being properly enabled in the training for the practical application . This study helps to know the different interaction related to the cardiovascular agent with own class of the drug and the other class of drugs used therapeutically to care the disease.

Keywords: Drug interactions, drug related problems, cardio vascular drugs, Micromedex

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References

1. Mahendra kumar bj et al., incidence and pattern of potential drug interactions of antimicrobial agents in the department of medicine in a tertiary care teaching hospital: a prospective study .Asian journal of pharmaceutical and clinical research2011.31-36.
2. Ragesh g. et al, a study on assessment of clinical pharmacy services to cardiology department in tertiary care teaching hospital,,Int j pharm pharm sci, vol 6, issue 2,192-195.
3. Raquel s. mendes-netto et al , assessment of drug interactions in elderly patients of a family health care unit in aracaju (brazil): a pilot study, African journal of pharmacy and pharmacology 2011 vol. 5(7), pp.812-818.
4. Ghulam murtaza et al, assessment of potential drug–drug interactions and its associated factors in the hospitalized cardiac p atients. saudi pharmaceutical journal (2015),1-6
5. Vesna bacic-vrca et al, the incidence of potential drug–drug interactions in elderly patients with arterial hypertension. Pharm world sci (2010)32:815–821.
6. S hegde et al, potential drug interactions in chronic kidney disease patients - a cross sectional study.International journal of recent trends in science and technology, 2015,56-60.
7. Crucial- Souza et al, Prevalence of potential drug drug interaction and its associated factors in a Brazilian Teaching Hospital. J Pharmapharmaceut.sci 2006. 9(3)427-33.
8. Mateti UV et al, drug drug interaction in a hospitalized cardiac patient. Journal of young pharmacist.2011;3(4)329-33.
9. GhulamMurtaza et al, Assessment of potential drug drug interaction and its associated factors in the hospitalized cardiac patient. Saudi Pharmaceutical journal2015;14
10. Mohammad Ismail et al, Potential drug drug interaction in cardiology ward of teachinghospital.2012.6(5);1618-24.
11. Legese Chelkeba et al, assessment of potential drug drug interaction among outpatient receiving cardiovascular medication at Jimma University specialized hospital, south west Ethiopia. Int.J basicClin Pharmacol.2013;2(2):144-152.
12. Fita Rahmawati et al, potentiality of drug drug interaction in hospitalized geriatrics patient in a private hospital .Asian journal of pharmaceutical and clinical research.2010;3(3)191-94.
13. Kiran Kumar et al, Clopidogrel -an Overview. International Journal of Pharmacology research2013;1(3):1-7.
14. LucaPasina et al, drug drug interaction in a cohort of hospitalized elderlypatient
.Pharmacoepidimiology and drug safety 2013; 22:1054-1060.
15. Steven P Dunn, Pharma.D et al,study of drug drug interaction in cardiovascular catheterization and intervention. JAACJournal,2012;5(12).
16. Jaidev Kumar et al, assessment of potential drug drug interaction in prescription of patient with chronic disease in a community setting .Journal of pharmaceutical Research.2015;14:47-47.
17. JigarKapadia et al ,a study of potential drug drug interaction in indoor patient of medicine Department at a tertiary care hospital. Journal of applied pharmaceutical sciences.oct2013;3(10),089-096.
18. Leelavathi D Acharya,et al, Potential drug interactions in patients admitted to cardiology wards of a south Indian teaching hospital. Australas Med J. 2011; 4(1):9–14.
19. Sushmita Sharma et al, A study of potential drug-drug interactions among hospitalized cardiac patients in a teaching hospital in Western Nepal. Indian Journal Pharmacology 2014;46(2)152-56.
20. L. Magro et al, Identification of severe potential drug-drug interactions using an Italian general-practitioner database. Eur J ClinPharmacol. DOI10.1007/s00228-007-0394-1.
21. BarnaGanguly et al, Potential Drug - Drug Interactions among Medications Prescribed to Hypertensive Patients. J ClinDiagn Res. 2014 Nov; 8(11):HC01–HC04.
22. Mohammad Haji Aghajani et al, Potential Drug-drug Interactions in Post-CCU of a Teaching Hospital. Iranian Journal of Pharmaceutical Research.2013;12(1)243-248.
23. G. Sepehri et al, Prevalence of Potential drug drug interaction in an Iranian general Hospital. Indian Journal of Pharmaceuticalscience.2012;74(1)75-79.
24. Raquel S. Mendes-Nettoeta Assessment of drug interactions in elderly patients of a family health care unit in Aracaju (Brazil): A pilot study. African Journal of Pharmacy and Pharmacology Vol. 5(7), pp. 812-818, July2011.
25. Trushar Umretiya et al,assessment of Potential Drug-Drug Interactions in the Department of Medicine at Basaweshwara Teaching and General Hospital Gulbarga.rguhs J Pharm SciVol 5 | Issue 3 | Jul-Sep,2015.
26. VesnaBacic-Vrca et al, The incidence of potential drug–drug interactions in elderly patients with arterial hypertension. Pharm World Sci (2010)32:815–821.
27. Jean André Hammes et al, Potential drug interactions prevalence in intensive careunits.
28. Cremaden J, Gonzalo M,Arrebola I. Relationship between drug interaction related negative clinical outcomes. PharmacyPract.2007;5:46-9
29. Hamim Zahir et al, Drug-Drug Interaction Studies of Cardiovascular Drugs Involving P-Glycoprotein,anEffluxTransporter,onthePharmacokineticsofEdoxaban,anOral
Factor Xa Inhibitor. American Journal of cardiovascular drugs.October 2013, Volume
13, Issue 5, pp 331–42.
30. Bista D, Palaian S, Shankar PR, Prabhu MM, Paudel R, Mishra P. Under standing the essential of drug interaction: A potential need for safe and effective use of drugs. Kathmandu University medical journal 2006; 1(3):421-430.
Published
30-04-2019
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Subrahmanyam, D., D. V. Lakshmi, D. Nagaraju, and D. Kumar. “ROLE OF CLINICAL PHARMACIST IN ASSESSMENT OF DRUG RELATED PROBLEMS OF CARDIO VASCULAR AGENTS IN DEPARTMENT OF CARDIOLOGY IN A TERTIARYCARE HOSPITAL – A PROSPECTIVE OBSERVATIONAL STUDY”. World Journal of Current Medical and Pharmaceutical Research, Vol. 1, no. 2, Apr. 2019, pp. 63-73, https://wjcmpr.com/index.php/journal/article/view/14.
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Research Articles