Onychomadesis Following Hand-Foot Mouth disease Prospective Observational Study on 33 cases of Hand Foot Mouth Disease

  • Zahoor Hussain Daraz Consultant Pediatrics, HA Alif Atoll Hospital, Dhidhdhoo Ministry of Health, Maldives.
  • Berkheez Shabir Consultant Gynecologist, HA Alif Atoll Hospital, Dhidhdhoo Ministry of Health, Maldives.
  • Rehana Afshan Consultant Radiologist G.B Pant Children Hospital, Sonwar, Srinagar, Kashmir-India.
  • Pramesh Kumar Yadav Medical Officer, HA Alif Atoll Hospital, Dhidhdhoo Ministry of Health,Maldives.
  • Adnan Bacha Assistant Professor, Dept. of general Surgery Southern Medical College, Chittagong, Bangladesh.


In 2019, an outbreak of hand, foot and mouth disease (HFMD)occurred in Maldives and many patients presented with onychomadesis following HFMD. Here we present a study of 33 cases out of which a total of 06 cases developed onychomadesis. Patients varied in clinical presentations ranging from mild to severe form of HFMD and during follow up 06 cases presented with peroidic shedding of nails involving both fingernails and toenails. All the patients were observed 4 to 6 weeks after diagnosis of HMFD was made. It was observed that onychomadesis developed was not related to the severity of the disease. Patients required only symptomatic treatment for HFMD and observation with assurance for onychomadesis as course was self-limited. Nail changes were temporary in nature and spontaneous regrowth occurred after shedding of the nails. Parental counselling played a cruicial role in management.

Keywords: HFMD-Hand Foot Mouth Disease, Onychomadesis


Download data is not yet available.


1. Daniel, C.R., Scher, R.K.: Nail changes secondary to systemic drugs or ingestants. In: J Am AcadDermatol.(1984), vol. 10, p. 250–258.
2. Bernier, V., Labreze, C., Bury, F., Taieb, A.: Nail matrix arrest in the course of hand, foot and mouth disease. In: Eur J Pediatr (2001), vol. 160(11), p. 649-651.
3. Hardin J, Haber RM. Onychomadesis: Literature Review. Br J Dermatol 2015; 172: 592-6.

4. Kim EJ, Park HS, Yoon HS, Cho S. Four Cases of Onychomadesis after Hand-Foot-Mouth Disease. Ann Dermatol 2014; 26: 777-8.
5. Repass GL, Palmer WC, Stancampiano FF. Hand, foot, and mouth disease: identifying and managing an acute viral syndrome. Cleve Clin J Med 2014; 81: 537-43.
6. Tan ZH, Koh MJ. Nail shedding following hand, foot and mouth disease. Arch Dis Child. 2013;98:665.
7. Cabrerizo, M., De Miguel, T., Armada, A., Martinez-Risco, R., Pousa, A., Trallero, G.: Onychomadesis after a hand, foot, and mouth disease outbreak in Spain, 2009. In: Epidemiol Infect (2010), vol. 138(12), p. 1775-1778.
8. Davia, J.L., Bel, P.H., Ninet, V.Z., Bracho, M.A., Gonzalez-Candelas, F., Salazar, A., et al.: Onychomadesisoutbreak in Valencia, Spain associatedwith hand, foot, and mouth diseasecaused by enteroviruses. In: PediatrDermatol (2011), vol. 28(1), p. 1-5.
9. Haneke, E.: Onychomadesis and hand, foot and mouth disease–is there a connection? In: Euro Surveill (2010),vol. 15(37), p. 19664.
10. Stock I. Hand, foot and mouth disease-more than a harmless “childhood disease”. Med Monatsschr Pharm 2014; 37: 4-10; quiz 11-2.
75 Views | 47 Downloads
How to Cite
Daraz, Z. H., B. Shabir, R. Afshan, P. K. Yadav, and A. Bacha. “Onychomadesis Following Hand-Foot Mouth Disease Prospective Observational Study on 33 Cases of Hand Foot Mouth Disease”. World Journal of Current Medical and Pharmaceutical Research, Vol. 2, no. 2, May 2020, pp. 139-41, doi:10.37022/WJCMPR.2020.2209.
Case Studys