A Comparison of the Efficacy of Gymnema Sylvestre 6 Ch and Gymnema Sylvestre Mother Tincture in Cases of Type 2 Diabetes Mellitus
Abstract
Diabetes Mellitus is metabolic disorder characterized by hyperglycemia resulting from inadequate insulin secretion, insulin action or both and insulin resistance. Gymnema sylvestre have reported beneficial effect for treating in type 2 diabetes mellitus.
Objective: A comparison of the efficacy of homoeopathic medicine gymnema sylvestre 6 CH and gymnema sylvestre mother tincture in the treatment of type 2 diabetes mellitus cases.
Material and method: 30 cases of type 2 diabetes mellitus were selected and gymnema sylvestre mother tincture and 6 CH were prescribed for these cases and follow up was every one month, three months and six months.
Results: Over a period of 6 months, there was significant reduction in blood sugar levels (fasting and post prandial blood sugar) in both groups. ANOVA repeated measures also showed significant difference P = 0.001.
Conclusion: There is significant reduction in fasting blood sugar, post prandial blood sugar levels both groups (gymnema sylvestre 6 CH and gymnema sylvestre homoeopathic mother tincture) in type 2 diabetes mellitus cases. The results suggested that gymnema sylvestre 6 CH and gymnema sylvestre mother tincture has beneficial anti diabetic effective and warrants future investigation.
Keywords:
Gymnema sylvestre, Homoeopathy, Type 2 diabetes
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References
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32. Ali, M. K., Narayan, K. M. & Tandon, N (2010). Diabetes and coronary heart disease: current perspectives. Indian J. Med. Res. 132, 584–597.
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34. Walters, D. P., Gatling, W., Mullee, M. A. & Hill, R. D(1992). The prevalence, detection, and epidemiological correlates of peripheral vascular disease: a comparison of diabetic and non diabetic subjects in an English community. Diabet. Med. 9; 710–715.
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39. Li, G (2002). Effects of insulin resistance and insulin secretion on the efficacy of interventions to retard development of type 2 diabetes mellitus: the DA Qing IGT and Diabetes Study. Diabetes Res. Clin. Pract. 58; 193–200.
40. Knowler, W. C (2002). Reduction in the incidence of type 2 diabetes with lifestyle intervention or M.form. N. Engl. J. Med. 346, 393–403.
41. Tuomilehto, J (2001). Prevention of Type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N. Engl. J. Med. 344, 1343–1350.
42. Boericke W (1999). Pocket Manual of Homoeopathic Materia Medica. Reprint Edition. B. Jain Publishers Pvt. Ltd, New Delhi.pp.1062.
43. Varma P N, Kusum Yadav, Ashok Kumar (2016). A compendium of rare and clinically established mother tinctures. Dr. William Schwabe India Pvt Ltd. India. pp 95.
44. Patel K, Srinivasan K (1997). Plant foods in the management of diabetes mellitusn. Vegetables as potential hypoglycaemic agents. Nahrung; 41:68-74.
45. Day C (1998). Traditional plant treatments for diabetes mellitus: Pharmaceutical foods. Br J Nutr.80; 203-208.
46. Mankil J, Moonsoo P, Hyun CL, Yoon Ho K, Eun SK, Sang KK (2006). Antidiabetic agents from medicinal plants. Curr Med Chem. 13; 1203-1212.
47. Maxine A Papadakis, Stephen J McPhee, Michael W Rabow (2015). Current Medical Diagnosis & Treatment, 54th ed. New York: McGraw Hill Education. pp. 218- 240
2. Zimmet, P. Z. Kelly West Lecture (1991). Challenges in diabetes epidemiology. Diabetes Care 15, 232–252.
3. Dowse, G. K (1990). High prevalence of NIDDM and impaired glucose tolerance in Indian, Creole, and Chinese Mauritians. Diabetes 39, 390–396.
4. Zimmet P (1983). Prevalence of diabetes and impaired glucose tolerance in the biracial (Melanesian and Indian) population of Fiji: a rural–urban comparison. Am. J. Epidemiol. 118, 673–688.
5. United Nations Geographic Region Classification (2016). Information bulletin.42.p.20-27.
6. Patel, J. C (1963). A sample survey to determine the incidence of diabetes in bombay. J. Indian Med. Assoc. 41, 448–452.
7. The K.E.M (1966). Hospital Group. in Diabetes in the Tropics (eds Patel, J. C. & Talwalker, N. G.) 1–79.
8. Berry, J. N., Chakravarty, R. N., Gupta, H. D. & Malik, K (1966). Prevalence of diabetes mellitus in a north Indian town. Indian J. Med. Res. 54, 1025–1047.
9. Gour, K. N (1966). Diabetes in the Tropics (eds Patel, J. C. & Talwalker, N. G.) 76–79.
10. Rao, P. S (1966). Diabetes in the Tropics (eds Patel, J. C. & Talwalker, N. G.) 68–75.
11. Viswanathan, M., Moses, S. G. P. & Krishnamoorty, M (1966). Diabetes in the Tropics (eds Patel, J. C., & Talwalker, N. G.) 29–32.
12. Pandit, K., Goswami, S., Ghosh, S., Mukhopadhyay, P. & Chowdhury, S (2012). Metabolic syndrome in South Asians. Indian J. Endocrinol. Metab. 16, 44–55.
13. Beckles, G. L (1986). High total and cardiovascular disease mortality in adults of Indian descent in Trinidad, unexplained by major coronary risk factors. Lancet 1, 1293–1301.
14. Simmons, D., Williams, D. R. & Powell, M. J (1989). Prevalence of diabetes in a predominantly Asian community: preliminary findings of the Coventry diabetes study. BMJ 298, 18–21.
15. Omar, M. A. K. & Motala, A. A (1996). Diabetes in South African Indians. Int. J. Diabetes Dev. Ctries 16, 45–47.
16. Oza Frank, R., Ali, M. K., Vaccarino, V. & Narayan, K. M (2009). Asian Americans: diabetes prevalence across U.S. and World Health Organization weight classifications. Diabetes Care 32, 1644–1646.
17. Oza-Frank, R. & Narayan, K. M (2010). Overweight and diabetes prevalence among US immigrants. Am. J. Publ. Health 100, 661–668.
18. National Registry of Diseases Office (2011). Information paper on diabetes in Singapore. 12-17.
19. Wan Nazaimoon, W. M (2013). Prevalence of diabetes in Malaysia and usefulness of HbA1c as a diagnostic criterion. Diabet. Med. 30, 825–828.
20. Lin, S (2015). Diabetes and obesity trends in Fiji over 30 years. J. Diabetes http://dx.doi.org/10.1111/ 1753-0407.12326.
21. Mohan, V (1986). Serum immunoreactive insulin responses to a glucose load in Asian Indian and European type 2 (non-insulin-dependent) diabetic patients and control subjects. Diabetologia 29, 235–237.
22. Misra, A (2004). High prevalence of insulin resistance in postpubertal Asian Indian children is associated with adverse truncal body fat patterning, abdominal adiposity and excess body fat. Int. J. Obes. Relat. Metab. Disord. 28, 1217–1226.
23. Pradeepa, R (2015). Prevalence of generalized & abdominal obesity in urban & rural India — the ICMR-INDIAB Study (Phase I) [ICMR - INDIAB 3]. Indian J. Med. Res. 142, 139–150.
24. Bhardwaj, S (2015). High prevalence of abdominal, intra-abdominal and subcutaneous adiposity and clustering of risk factors among urban Asian Indians in North India. PLoS ONE 6; 24362.
25. Misra, A (2011). The high burden of obesity and abdominal obesity in urban Indian schoolchildren: a multicentric study of 38,296 children. Ann. Nutr. Metab. 58, 203–211.
26. Dandona, L., Dandona, R., Shamanna, B. R., Naduvilath, T. J. & Rao, G. N (1998). Developing a model to reduce blindness in India: the International Centre for Advancement of Rural Eye Care. Indian J. Ophthalmol. 46, 263–268.
27. Narendran, V (2002). Diabetic retinopathy among self reported diabetics in southern India: a population based assessment. Br. J. Ophthalmol. 86, 1014–1018.
28. Samanta, A., Burden, A. C., Feehally, J. & Walls, J (1986). Diabetic renal disease: differences between Asian and white patients. Br. Med. J. (Clin. Res. Ed.) 293, 366–367.
29. Mather, H. M., Chaturvedi, N. & Kehely, A. M (1998). Comparison of prevalence and risk factors for microalbuminuria in South Asians and Europeans with type 2 diabetes mellitus. Diabet. Med. 15, 672–677.
30. Chandie Shaw, P. K (2006). South Asian type 2 diabetic patients have higher incidence and faster progression of renal disease compared with Dutch-European diabetic patients. Diabetes Care 29, 1383–1385.
31. Abbott, C. A., Malik, R. A., van Ross, E. R., Kulkarni, J. & Boulton, A. J (2011). Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K. Diabetes Care 34, 2220–2224.
32. Ali, M. K., Narayan, K. M. & Tandon, N (2010). Diabetes and coronary heart disease: current perspectives. Indian J. Med. Res. 132, 584–597.
33. Mohan, V., Venkatraman, J. V. & Pradeepa, R (2010). Epidemiology of cardiovascular disease in type 2 diabetes: the Indian scenario. J. Diabetes Sci. Technol. 4, 158–170.
34. Walters, D. P., Gatling, W., Mullee, M. A. & Hill, R. D(1992). The prevalence, detection, and epidemiological correlates of peripheral vascular disease: a comparison of diabetic and non diabetic subjects in an English community. Diabet. Med. 9; 710–715.
35. Marso, S. P. & Hiatt, W. R (2006). Peripheral arterial disease in patients with diabetes. J. Am. Coll. Cardiol. 47, 921–929.
36. Singh, N., Armstrong, D. G. & Lipsky, B. A (2005). Preventing foot ulcers in patients with diabetes. JAMA 293, 217–228.
37. Viswanathan, V (2014). Effect of diabetes on treatment outcome of smear-positive pulmonary tuberculosis — a report from South India. J. Diabetes Complications 28, 162–165.
38. Viswanathan, Mohan (2016). Diabetes Mellitus and its complications in India. Nature Clinical Collection. Macmillan Medical communications, Gurgaon, India. Pp 151-164. DOI: 10.1038/nrendo.2016.53.
39. Li, G (2002). Effects of insulin resistance and insulin secretion on the efficacy of interventions to retard development of type 2 diabetes mellitus: the DA Qing IGT and Diabetes Study. Diabetes Res. Clin. Pract. 58; 193–200.
40. Knowler, W. C (2002). Reduction in the incidence of type 2 diabetes with lifestyle intervention or M.form. N. Engl. J. Med. 346, 393–403.
41. Tuomilehto, J (2001). Prevention of Type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N. Engl. J. Med. 344, 1343–1350.
42. Boericke W (1999). Pocket Manual of Homoeopathic Materia Medica. Reprint Edition. B. Jain Publishers Pvt. Ltd, New Delhi.pp.1062.
43. Varma P N, Kusum Yadav, Ashok Kumar (2016). A compendium of rare and clinically established mother tinctures. Dr. William Schwabe India Pvt Ltd. India. pp 95.
44. Patel K, Srinivasan K (1997). Plant foods in the management of diabetes mellitusn. Vegetables as potential hypoglycaemic agents. Nahrung; 41:68-74.
45. Day C (1998). Traditional plant treatments for diabetes mellitus: Pharmaceutical foods. Br J Nutr.80; 203-208.
46. Mankil J, Moonsoo P, Hyun CL, Yoon Ho K, Eun SK, Sang KK (2006). Antidiabetic agents from medicinal plants. Curr Med Chem. 13; 1203-1212.
47. Maxine A Papadakis, Stephen J McPhee, Michael W Rabow (2015). Current Medical Diagnosis & Treatment, 54th ed. New York: McGraw Hill Education. pp. 218- 240
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01-05-2020
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Adi BS, Adi GB, Jamadade AK, E SRR. A Comparison of the Efficacy of Gymnema Sylvestre 6 Ch and Gymnema Sylvestre Mother Tincture in Cases of Type 2 Diabetes Mellitus . World Journal of Current Med and Pharm Research [Internet]. 2020May1 [cited 2024Dec.6];2(2):133-8. Available from: https://wjcmpr.com/index.php/journal/article/view/113
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